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LFM-A13

Catalog No. T6217 CAS 244240-24-2

LFM-A13（IC50=2.5 μM）, a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and IRK.

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LFM-A13, CAS 244240-24-2

Pack Size	Availability	Price/USD
2 mg	In stock	$ 31.00
5 mg	In stock	$ 47.00
10 mg	In stock	$ 74.00
25 mg	In stock	$ 167.00
50 mg	In stock	$ 283.00
100 mg	In stock	$ 479.00
1 mL * 10 mM (in DMSO)	In stock	$ 47.00

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Purity: 99.9%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	LFM-A13（IC50=2.5 μM）, a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and IRK.
Targets&IC50	BTK:2.5 μM
In vitro	In BTK+ B-lineage leukemic cells, LFM-A13 enhances their sensitivity to ceramide- or vincristine-induced apoptosis. [1] In BCL-1 cells, NALM-6 cells, or normal BALB/c splenocytes, LFM-13 inhibits the enzymatic activity of BTK in BCL-1 cells without affecting the BTK protein expression levels [2] In human neutrophils, LFM-A13 decreases the tyrosine phosphorylation induced by fMet-Leu-Phe and inhibits the production of superoxide anions and the stimulation of adhesion, chemotaxis, and phospholipase D activity. [3]
In vivo	In BALB/c mice bearing BCL-1 leukemia, combination of LFM-A13 (50 mg/kg/day i.p.) and the standard triple-drug VPL prolongs the median survival time. [2] In primary myeloma-bearing SCID-rab mice, LFM-A13 inhibits osteoclast activity, prevents myeloma-induced bone resorption and suppresss myeloma growth. [4]

Molecular Weight	360
Formula	C11H8Br2N2O2
CAS No.	244240-24-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 67 mg/mL (186.1 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Mahajan S, et al. J Biol Chem. 1999, 274(14), 9587-9599. 2. Uckun FM, et al. Clin Cancer Res. 2002, 8(5), 1224-1233. 3. Gilbert C, et al. J Immunol. 2003, 170(10), 5235-5243. 4. Bam R, et al. Am J Hematol. 2013, 88(6), 463-471.

Citations

1. Wan J, Yu X, Niu J Q, et al. Inhibition of Bruton's Tyrosine Kinase Protects Against Burn Sepsis-Induced Intestinal Injury. Frontiers in Medicine. 2022, 9.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Highly Selective Inhibitor Library Inhibitor Library Anti-Cancer Active Compound Library Anti-Prostate Cancer Compound Library Anti-Cancer Compound Library Reprogramming Compound Library Stem Cell Differentiation Compound Library Anti-Lung Cancer Compound Library Anti-Aging Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

LFM-A13 244240-24-2 Angiogenesis Cell Cycle/Checkpoint Chromatin/Epigenetic JAK/STAT signaling Stem Cells Tyrosine Kinase/Adaptors PLK JAK BTK Janus kinase LFM-A-13 Inhibitor LFMA13 Polo-like Kinase (PLK) Bruton tyrosine kinase Btk LFM A13 inhibit inhibitor

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