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LG100754

Catalog No. T15748 CAS 180713-37-5

Synonyms: UVI 2112

LG100754 (UVI 2112) is an insulin sensitizer that functions through RXR. LG100754 is an RXR dimer modulator. LG100754 acts as an RXR: RXR homodimer antagonist, but functions as an agonist towards RXR: PPARα and RXR: PPARγ heterodimers.

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LG100754, CAS 180713-37-5

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 993.00
50 mg	6-8 weeks	$ 1,290.00
100 mg	6-8 weeks	$ 1,970.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	LG100754 (UVI 2112) is an insulin sensitizer that functions through RXR. LG100754 is an RXR dimer modulator. LG100754 acts as an RXR: RXR homodimer antagonist, but functions as an agonist towards RXR: PPARα and RXR: PPARγ heterodimers.
In vitro	LG100754 functions as an activator of endogenous RXR heterodimers, specifically facilitating the activity of RXR: PPARγ heterodimers. It plays a crucial role in regulating insulin-dependent signaling pathways. Additionally, LG100754 has been shown to mitigate TNFα-mediated insulin resistance in mature adipocytes[1].
In vivo	LG100754 (100 mg/kg) fully blocks the enhance in glucose levels. It also shows that LG100754 can improve insulin resistance in vivo[1].

Synonyms	UVI 2112
Molecular Weight	396.56
Formula	C26H36O3
CAS No.	180713-37-5

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90.0 mg/mL (227.0 mM), Sonication is recommended.

References and Literature

1. Cesario RM, et al. The rexinoid LG100754 is a novel RXR:PPARgamma agonist and decreases glucose levels in vivo. Mol Endocrinol. 2001 Aug;15(8):1360-9.

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Keywords

LG100754 180713-37-5 DNA Damage/DNA Repair Metabolism PPAR LG-100754 UVI-2112 LG 100754 UVI2112 UVI 2112 inhibitor inhibit

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