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LP99

Catalog No. T15784 CAS 1808951-93-0

LP99 is an epigenetic probe. LP99 disrupts the binding of BRD7 and BRD9 to chromatin in cells. LP99 is an effective and selective inhibitor of the BRD7 and BRD9 bromodomains (Kd: 99 nM against BRD9).

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LP99, CAS 1808951-93-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 60.00
5 mg	In stock	$ 147.00
10 mg	In stock	$ 247.00
25 mg	In stock	$ 537.00
50 mg	In stock	$ 775.00
100 mg	In stock	$ 1,080.00
1 mL * 10 mM (in DMSO)	In stock	$ 167.00

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Purity: 98.74%

Biological Description

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Storage & Solubility Information

Description	LP99 is an epigenetic probe. LP99 disrupts the binding of BRD7 and BRD9 to chromatin in cells. LP99 is an effective and selective inhibitor of the BRD7 and BRD9 bromodomains (Kd: 99 nM against BRD9).
Targets&IC50	BRD9:(kd)99 nM
In vitro	LP99 (0.8 μM) disrupts BRD9 interactions with chromatin. The addition of LP99 decreased BRET for both BRD7 and BRD9 in both the H3.3 and H4 systems in a dose-dependent manner, with cellular IC50 values in the low micromolar range for both histone. LP99 inhibits IL-6 secretion from THP-1 cells in a dose-dependent manner. Cytotoxicity tests in U2OS cells for 24 and 72 hours display the inhibitor to be non-toxic at concentrations of <33 μM .

Molecular Weight	516.05
Formula	C26H30ClN3O4S
CAS No.	1808951-93-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5 mg/mL (43.6 mM)

References and Literature

1. Clark PG, et al. LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor. Angew Chem Int Ed Engl. 2015 May 18;54(21):6217-21.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library PPI Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max Histone Modification Compound Library Epigenetics Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

LP99 1808951-93-0 Chromatin/Epigenetic Epigenetic Reader Domain selective organocatalysis cytokine LP-99 LP 99 epigenetics probe bromodomain pro-inflammatory inhibit Inhibitor secretion histones inhibitor

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