Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LPA2 antagonist 2 is >480-fold more selective than LPA3 (IC50 of 13.85 μM).LPA2 antagonist 2 is a selective LPA2 antagonist with an IC50 of 28.3 nM and a Ki of 21.1 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 882.00 | |
50 mg | 6-8 weeks | $ 1,170.00 | |
100 mg | 6-8 weeks | $ 1,770.00 |
Description | LPA2 antagonist 2 is >480-fold more selective than LPA3 (IC50 of 13.85 μM).LPA2 antagonist 2 is a selective LPA2 antagonist with an IC50 of 28.3 nM and a Ki of 21.1 nM. |
Targets&IC50 | LPA3:13.85 μM , LPA2:28.3 nM |
In vitro | Lysophosphatidic acid (LPA) is a phospholipid mediator that elicits a host of biological effects including cell proliferation, survival, motility and differentiation. ?LPA2 antagonist 2 inhibits LPA1 with an Imax of 59.0% at 30 μM[1].?LPA has been shown to regulate cancer cell invasion, metastasis, and resistance to both chemotherapeutics and radiation. |
Molecular Weight | 380.35 |
Formula | C20H16N2O6 |
CAS No. | 36840-10-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 83.33 mg/mL (219.09 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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LPA2 antagonist 2 36840-10-5 GPCR/G Protein LPA Receptor LPA-2 antagonist 2 inhibitor inhibit