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LPA2 antagonist 2

Catalog No. T11875   CAS 36840-10-5

LPA2 antagonist 2 is >480-fold more selective than LPA3 (IC50 of 13.85 μM).LPA2 antagonist 2 is a selective LPA2 antagonist with an IC50 of 28.3 nM and a Ki of 21.1 nM.

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LPA2 antagonist 2 Chemical Structure
LPA2 antagonist 2, CAS 36840-10-5
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25 mg 6-8 weeks $ 882.00
50 mg 6-8 weeks $ 1,170.00
100 mg 6-8 weeks $ 1,770.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description LPA2 antagonist 2 is >480-fold more selective than LPA3 (IC50 of 13.85 μM).LPA2 antagonist 2 is a selective LPA2 antagonist with an IC50 of 28.3 nM and a Ki of 21.1 nM.
Targets&IC50 LPA3:13.85 μM , LPA2:28.3 nM
In vitro Lysophosphatidic acid (LPA) is a phospholipid mediator that elicits a host of biological effects including cell proliferation, survival, motility and differentiation. ?LPA2 antagonist 2 inhibits LPA1 with an Imax of 59.0% at 30 μM[1].?LPA has been shown to regulate cancer cell invasion, metastasis, and resistance to both chemotherapeutics and radiation.
Molecular Weight 380.35
Formula C20H16N2O6
CAS No. 36840-10-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 83.33 mg/mL (219.09 mM), sonification is recommended.

TargetMolReferences and Literature

1. Fells JI, et al. Identification of non-lipid LPA3 antagonists by virtual screening. Bioorg Med Chem. 2008 Jun 1;16(11):6207-17.

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Keywords

LPA2 antagonist 2 36840-10-5 GPCR/G Protein LPA Receptor LPA-2 antagonist 2 inhibitor inhibit

 

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