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LY-402913

Catalog No. T27954   CAS 334970-65-9
Synonyms: LY 402913, LY402913

LY-402913 is a selective multidrug resistance protein (MRP1) inhibitor.

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LY-402913 Chemical Structure
LY-402913, CAS 334970-65-9
Pack Size Availability Price/USD Quantity
1 mg In stock $ 195.00
2 mg In stock $ 293.00
5 mg In stock $ 447.00
10 mg In stock $ 659.00
25 mg In stock $ 987.00
50 mg In stock $ 1,380.00
100 mg In stock $ 1,890.00
1 mL * 10 mM (in DMSO) In stock $ 563.00
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Purity: 100%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description LY-402913 is a selective multidrug resistance protein (MRP1) inhibitor.
In vitro LY-402913 inhibits MRP1 and reverses drug resistance to MRP1 substrates, such as doxorubicin, in HeLa-T5 cells (EC50=0.90 μM), while showing no inherent cytotoxicity. LY-402913 inhibits ATP-dependent, MRP1-mediated LTC4 uptake into membrane vesicles prepared from the MRP1-overexpressing HeLa-T5 cells (EC50=1.8 μM). LY-402913 also shows selectivity (∼22-fold) against the related transporter, P-glycoprotein, in HL60/Adr and HL60/Vinc cells[2].
In vivo When dosed in combination with the oncolytic MRP1 substrate vincristine, LY-402913 delays the growth of MRP1-overexpressing tumors in vivo[2].
Synonyms LY 402913, LY402913
Molecular Weight 533.96
Formula C28H24ClN3O6
CAS No. 334970-65-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (93.64 mM)

TargetMolReferences and Literature

1. Tawari NR, Bag S, Degani MS. Pharmacophore mapping of a series of pyrrolopyrimidines, indolopyrimidines and their congeners as multidrug-resistance-associated protein (MRP1) modulators. J Mol Model. 2008 Oct;14(10):911-21. 2. Norman BH, Gruber JM, Hollinshead SP, Wilson JW, Starling JJ, Law KL, Self TD, Tabas LB, Williams DC, Paul DC, Wagner MM, Dantzig AH. Tricyclic isoxazoles are novel inhibitors of the multidrug resistance protein (MRP1). Bioorg Med Chem Lett. 2002 Mar 25;12(6):883-6. PubMed PMID: 11958985.

Related compound libraries

This product is contained In the following compound libraries:
Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max

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Keywords

LY-402913 334970-65-9 Immunology/Inflammation MRP LY 402913 LY402913 inhibitor inhibit

 

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