Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LY-402913 is a selective multidrug resistance protein (MRP1) inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 195.00 | |
2 mg | In stock | $ 293.00 | |
5 mg | In stock | $ 447.00 | |
10 mg | In stock | $ 659.00 | |
25 mg | In stock | $ 987.00 | |
50 mg | In stock | $ 1,380.00 | |
100 mg | In stock | $ 1,890.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 563.00 |
Description | LY-402913 is a selective multidrug resistance protein (MRP1) inhibitor. |
In vitro | LY-402913 inhibits MRP1 and reverses drug resistance to MRP1 substrates, such as doxorubicin, in HeLa-T5 cells (EC50=0.90 μM), while showing no inherent cytotoxicity. LY-402913 inhibits ATP-dependent, MRP1-mediated LTC4 uptake into membrane vesicles prepared from the MRP1-overexpressing HeLa-T5 cells (EC50=1.8 μM). LY-402913 also shows selectivity (∼22-fold) against the related transporter, P-glycoprotein, in HL60/Adr and HL60/Vinc cells[2]. |
In vivo | When dosed in combination with the oncolytic MRP1 substrate vincristine, LY-402913 delays the growth of MRP1-overexpressing tumors in vivo[2]. |
Synonyms | LY 402913, LY402913 |
Molecular Weight | 533.96 |
Formula | C28H24ClN3O6 |
CAS No. | 334970-65-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (93.64 mM)
You can also refer to dose conversion for different animals. More
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LY-402913 334970-65-9 Immunology/Inflammation MRP LY 402913 LY402913 inhibitor inhibit