Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LY117018 shows antiproliferative effects on breast cancer cell lines. LY117018 is a Raloxifene analog and is a selective estrogen receptor modulator.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | LY117018 shows antiproliferative effects on breast cancer cell lines. LY117018 is a Raloxifene analog and is a selective estrogen receptor modulator. |
In vitro | LY117018 (1 μM) treatment, caused a predominantly hypophosphorylated pRb. At a higher concentration of LY117018 (1 μM), the level of p53 appeared to decline. LY117018 (0.01-1000 nM; 24 hours) at lower concentrations (0.01-10 nM) caused an E2-like increase in p53 levels when compared to its effects on cells grown in the stripped medium. LY117018 did not block E2-induced pRb phosphorylation, at lower concentrations[1]. LY117018 (1 μM; 96 hours) suppresses MCF-7 cell proliferation with an IC50 of 1 μM[2]. LY117018 inhibits oxidative stress-induced endothelial cell apoptosis through activation of ERK1/2 signaling pathway[3]. |
Molecular Weight | 459.56 |
Formula | C27H25NO4S |
CAS No. | 63676-25-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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LY117018 63676-25-5 PI3K/Akt/mTOR signaling PI3K LY-117018 LY 117018 inhibitor inhibit