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Latanoprost acid

Catalog No. T15718 CAS 41639-83-2

Latanoprost acid is a selective agonist of prostanoid receptors and inhibits RANKL-induced osteoclastogenesis and function through the inhibition of c-fos/NFATc1 pathway. Latanoprost acid can be used in studies about lowering pressure inside the eyes.

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Latanoprost acid, CAS 41639-83-2

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Purity: 98%

Biological Description

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Description	Latanoprost acid is a selective agonist of prostanoid receptors and inhibits RANKL-induced osteoclastogenesis and function through the inhibition of c-fos/NFATc1 pathway. Latanoprost acid can be used in studies about lowering pressure inside the eyes.
In vitro	Latanoprost acid (10, 20 μM) reduces the protein expressions of c-fos and NFATc1 thus inhibiting the mature osteoclast formation in BMMs. Latanoprost acid (10μM) and RANKL(50ng/ml) significantly inhibit ERK, p38, AKT and JNK[1].
In vivo	Latanoprost acid (i.p.; 20 mg/kg; once a day for 7 days) treatment obviously prevents LPS-induced bone destruction [1].

Molecular Weight	390.52
Formula	C23H34O5
CAS No.	41639-83-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Weinreb RN, et al. Effects of prostaglandins on the aqueous humor outflow pathways. Surv Ophthalmol. 2002 Aug;47 Suppl 1:S53-64. 2. Xu X, et al. The prevention of latanoprost on osteoclastgenesis in vitro and lipopolysaccharide-induced murine calvaria osteolysis in vivo. J Cell Biochem. 2018 Jun;119(6):4680-4691.

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Keywords

Latanoprost acid 41639-83-2 其他 Others Inhibitor inhibitor inhibit

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