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GPCR/G Protein GNRH Receptor Leuprorelin

Leuprorelin

Catalog No. T5018   CAS 53714-56-0
Synonyms: Leuprolide, Leuprolide

Leuprolide is an agonist at pituitary GnRH receptors.GnRH receptor Leuprorelin is a gonadotrophin-releasing hormone (GnRH) analogue used to treat a wide range of sex hormone-related disorders including advanced prostatic cancer, endometriosis and precocious puberty. Leuprorelin acts primarily on the anterior pituitary, inducing a transient early rise in gonadotrophin release. With continued use, Leuprorelin causes pituitary desensitisation and/or down-regulation, leading to suppressed circulating levels of gonadotrophins and sex hormones.By interrupting the normal pulsatile stimulation of, and thus desensitizing, the GnRH receptors, it indirectly downregulates the secretion of gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to hypogonadism and thus a dramatic reduction in estradiol and testosterone levels in both sexes.

Leuprorelin, CAS 53714-56-0
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Leuprolide is an agonist at pituitary GnRH receptors.GnRH receptor Leuprorelin is a gonadotrophin-releasing hormone (GnRH) analogue used to treat a wide range of sex hormone-related disorders including advanced prostatic cancer, endometriosis and precocious puberty. Leuprorelin acts primarily on the anterior pituitary, inducing a transient early rise in gonadotrophin release. With continued use, Leuprorelin causes pituitary desensitisation and/or down-regulation, leading to suppressed circulating levels of gonadotrophins and sex hormones.By interrupting the normal pulsatile stimulation of, and thus desensitizing, the GnRH receptors, it indirectly downregulates the secretion of gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to hypogonadism and thus a dramatic reduction in estradiol and testosterone levels in both sexes.
Targets&IC50 GNRHR,  
Synonyms Leuprolide , Leuprolide
Purity
Molecular Weight 1209.4
Formula C59H84N16O12
CAS No. 53714-56-0

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 10mM

Water: 1mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Plosker GL, Leuprorelin. A review of its pharmacology and therapeutic use in prostatic cancer, endometriosis and other sex hormone-related disorders. Drugs.1994 Dec;48(6):930-967.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Anti-cancer Compound Library Anti-cancer Approved drug Library

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Degarelix Danazol Relugolix Goserelin acetate Leuprorelin Leuprolide Acetate Elagolix sodium Cetrorelix

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