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Levcromakalim

Catalog No. TQ0150   CAS 94535-50-9
Synonyms: (-)-Cromakalim, BRL 38227

Levcromakalim (BRL 38227) is an activator of the ATP-sensitive K+ channel.

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Levcromakalim Chemical Structure
Levcromakalim, CAS 94535-50-9
Pack Size Availability Price/USD Quantity
1 mg In stock $ 48.00
2 mg In stock $ 71.00
5 mg In stock $ 101.00
10 mg In stock $ 153.00
25 mg In stock $ 353.00
50 mg In stock $ 525.00
100 mg In stock $ 759.00
1 mL * 10 mM (in DMSO) In stock $ 112.00
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Purity: 99.91%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Levcromakalim (BRL 38227) is an activator of the ATP-sensitive K+ channel.
In vitro Levcromakalim inhibits spontaneous contractions completely in a glibenclamide-sensitive manner. LevCromakalim (5 μM) inhibits spontaneous contractions, which are recovered by glibenclamide. Levcromakalim (1, 5 and 10 μM) inhibits phasic contractions to 34±21.1%, 20.1±20.0% and 0% of the control. Glibenclamide reverses the inhibition of spontaneous isometric contractions caused by LevCromakalim (5 μM) to 84±1.5% of the control. Levcromakalim (20 and 100 μM) also inhibits oxytocin (OXT) (10 nM)-induced phasic contractions to 34±21.4% and 14±12.6% of the control [2]. LevCromakalim induces dose-dependent relaxation in both the young and old mesenteric artery (MAs); there is no difference in relaxation with age. However, the relaxation is markedly reduced in response to the high-salt (HS) diet in the old MAs (P<0.05). Maximum dilations to Levcromakalim (10-4 M) are 97 ± 3% in the young MAs versus 98 ± 1% in the young salt arteries, while dilations are 99±0.7% in the old MAs when compared with 85 ± 5% in the old salt arteries (P<0.05) [3].
Synonyms (-)-Cromakalim, BRL 38227
Molecular Weight 286.33
Formula C16H18N2O3
CAS No. 94535-50-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

DMSO: 50 mg/mL (174.62 mM )

TargetMolReferences and Literature

1. Matsumoto T, et al. Tunicamycin-Induced Alterations in the Vasorelaxant Response in Organ-Cultured Superior Mesenteric Arteries of Rats. Biol Pharm Bull. 2016;39(9):1475-81. 2. Hong SH, et al. Regulation of myometrial contraction by ATP-sensitive potassium (KATP) channel via activation of SUR2B and Kir 6.2 in mouse. J Vet Med Sci. 2016 Aug 1;78(7):1153-9. 3. Whidden MA, Altered potassium ATP channel signaling in mesenteric arteries of old high salt-fed rats. J Exerc Nutrition Biochem. 2016 Jun;20(2):58-64.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Ion Channel Inhibitor Library NO PAINS Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library Potassium Channel Blocker Library

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Keywords

Levcromakalim 94535-50-9 Membrane transporter/Ion channel Potassium Channel KcsA BRL38227 Inhibitor (-)-Cromakalim inhibit BRL-38227 BRL 38227 Cromakalim inhibitor

 

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