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Levocetirizine Dihydrochloride

Catalog No. T22354 CAS 130018-87-0

Synonyms: Xyzal Dihydrochloride, (-)-Cetirizine Dihydrochloride

Levocetirizine Dihydrochloride (Xyzal Dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Acting as an antihistaminic agent, it specifically targets the histamine H1-receptor. Levocetirizine Dihydrochloride is the R-enantiomer of Cetirizine, which gives it a higher affinity for the H1-receptor than the S-enantiomer. Due to this enhanced affinity, Levocetirizine Dihydrochloride is effective in treating allergic rhinitis and chronic idiopathic urticaria.

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Levocetirizine Dihydrochloride Chemical Structure

Levocetirizine Dihydrochloride, CAS 130018-87-0

Pack Size	Availability	Price/USD
10 mg	In stock	$ 43.00
25 mg	In stock	$ 78.00
50 mg	In stock	$ 133.00
100 mg	In stock	$ 198.00
200 mg	In stock	$ 297.00
500 mg	In stock	$ 513.00
1 g	In stock	$ 729.00
1 mL * 10 mM (in DMSO)	In stock	$ 48.00

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Purity: 99.75%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vivo

Levocetirizine (0.4 mg/kg; oral administration; male Sprague-Dawley rats) treatment shows that the Cmax, AUC0-t, AUC0-∞ and t1/2 are 0.34 μg/mL, 3.26 μg h/mL, 3.67 μg h/mL and 2.34 hours, respectively in Sprague-Dawley rats[1].

Synonyms	Xyzal Dihydrochloride, (-)-Cetirizine Dihydrochloride
Molecular Weight	461.81
Formula	C21H27Cl3N2O3
CAS No.	130018-87-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 90 mg/mL (194.9 mM), Sonication is recommended.

DMSO: 90 mg/mL (194.9 mM), Sonication is recommended.

References and Literature

1. Lohar P, et al. Simultaneous bioanalysis and pharmacokinetic interaction study of acebrophylline, levocetirizine and pranlukast in Sprague-Dawley rats. Biomed Chromatogr. 2019 Dec;33(12):e4672.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Inhibitor Library Membrane Protein-targeted Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library GPCR Compound Library Drug Repurposing Compound Library Bioactive Compounds Library Max FDA-Approved Drug Library Neuronal Signaling Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Levocetirizine Dihydrochloride 130018-87-0 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor Cetirizine Dihydrochloride Cetirizine Levocetirizine Xyzal Dihydrochloride (-)-Cetirizine Dihydrochloride Xyzal inhibitor inhibit

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