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Levodropropizine

Catalog No. T0217 CAS 99291-25-5

Synonyms: (S)-(-)-Dropropizine, DF-526

Levodropropizine ((S)-(-)-Dropropizine) is a histamine receptor inhibitor. It is used as an effective and very well tolerated peripheral antitussive drug.

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Levodropropizine, CAS 99291-25-5

Pack Size	Availability	Price/USD	Quantity
1 g	In stock	$ 42.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 100%

Purity: 99.93%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Levodropropizine ((S)-(-)-Dropropizine) is a histamine receptor inhibitor. It is used as an effective and very well tolerated peripheral antitussive drug.
In vitro	Research indicates that Levodropropizine effectively suppresses cough in anesthetized guinea pigs and rabbits. Intravenous administration of Levodropizine in these animals, during mechanically and electrically induced coughs, shows an activity ranging from one-tenth to one-twentieth of codeine, similar to hydroxyzine. Oral Levodropizine treatment for cough induced by irritant aerosols has effects comparable to hydroxyzine and codeine. An intravenous dose of 15 mg/kg Levodropropizine reduces the duration of asphyxiation and the C-fiber response to phenylbiguanide. Additionally, Levodropropizine dose-dependently decreases capsaicin-induced Evans blue dye extravasation in rat airways.
In vivo	Levodropropizine exhibits affinity for both H1 histamine and α-adrenergic receptors.

Synonyms	(S)-(-)-Dropropizine, DF-526
Molecular Weight	236.31
Formula	C13H20N2O2
CAS No.	99291-25-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 44 mg/mL (186.2 mM)

H2O: 12 mg/mL (50.8 mM)

DMSO: 44 mg/mL (186.2 mM)

References and Literature

1. Melillo G, et al. Arzneimittelforschung, 1988, 38(8), 1144-1150. 2. Shams H, et al. Br J Pharmacol, 1996, 117(5), 853-858. 3. Malandrino S, et al. Arzneimittelforschung, 1988 , 38(8), 1141-1143. 4. Lavezzo A, et al. Pulm Pharmacol, 1992, 5(2), 143-147. 5. Yamawaki I, et al. Eur J Pharmacol, 1993, 243(1), 1-6. 6. Zanasi A, et al. Levodropropizine for treating cough in adult and children: a meta-analysis of published studies. Multidiscip Respir Med. 2015 May 31;10(1):19.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library EMA Approved Drug Library Anti-Parkinson's Disease Compound Library Drug-Fragment Library Anti-Obesity Compound Library Approved Drug Library FDA-Approved & Pharmacopeia Drug Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Levodropropizine 99291-25-5 GPCR/G Protein Immunology/Inflammation Neuroscience 5-HT Receptor Histamine Receptor Dropropizine DF 526 inhibit Inhibitor (S)-(-)-Dropropizine DF-526 DF526 inhibitor

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