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Levonorgestrel

Catalog No. T1263 CAS 797-63-7

Synonyms: D-Norgestrel

Levonorgestrel (D-Norgestrel) is a Progestin and Progestin-containing Intrauterine Device. The physiologic effect of levonorgestrel is by means of Inhibit Ovum Fertilization.

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Levonorgestrel, CAS 797-63-7

Pack Size	Availability	Price/USD
100 mg	In stock	$ 42.00
200 mg	In stock	$ 47.00
1 mL * 10 mM (in DMSO)	In stock	$ 46.00

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Purity: 99.83%

Purity: 99.79%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Levonorgestrel (D-Norgestrel) is a Progestin and Progestin-containing Intrauterine Device. The physiologic effect of levonorgestrel is by means of Inhibit Ovum Fertilization.
In vitro	Levonorgestrel significantly upregulates mRNA expression of the gene encoding luteinizing hormone beta subunit (lhβ) in both male and female cockroaches, while downregulating mRNA expression of the gene encoding follicle-stimulating hormone beta subunit (fshβ). Furthermore, in long-clawed ground squirrels, Levonorgestrel decreases the mRNA expression of ovarian follicle-stimulating hormone receptor, luteinizing hormone receptor, ovarian estrogen receptor β, and progesterone receptor, as well as the mRNA expression of ERα and PR in the uterus.
In vivo	Levonorgestrel elevates cyclic AMP levels in the veins and inhibits the activation of protein kinase C induced by PMA. It suppresses progesterone secretion in rat luteal cells, which is stimulated by oLH, dibutyryl-cAMP, and pregnenolone. Levonorgestrel also inhibits contractions induced by high potassium (K(+)) solutions or PMA in the presence and absence of extracellular calcium (Ca(2+)), effectuating endothelium-dependent relaxation through hindrance of calcium ion ingress and protein kinase C activation. Moreover, while the inhibitory effects of Levonorgestrel on estrogen-induced pituitary weight gain and hyperprolactinemia are attenuated by mifepristone, flunarizine does not block its effects.

Synonyms	D-Norgestrel
Molecular Weight	312.45
Formula	C21H28O2
CAS No.	797-63-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 31.3 mg/mL (100 mM)

References and Literature

1. Tellería CM, et al. J Steroid Biochem Mol Biol. 1994 Aug;50(3-4):161-6. 2. Herkert O, et al. Br J Pharmacol,2000, 130(8), 1911-1918. 3. Sala-Mateus C, et al. Enferm Infecc Microbiol Clin. 1991 Feb;9(2):117-8. 4. Lv XH, et al. Exp Anim,2011, 60(4), 363-371. 5. Kroupova HK, et al. Aquat Toxicol,2014, 154, 154-162.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Inhibitor Library Bioactive Lipid Compound Library Natural Product Library Drug-induced Liver Injury (DILI) Compound Library Bioactive Compound Library ReFRAME Related Library Clinical Compound Library Approved Drug Library Human Metabolite Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Levonorgestrel 797-63-7 Endocrinology/Hormones Others Estrogen/progestogen Receptor Progesterone Receptor NR3C3 Inhibitor inhibit D-Norgestrel inhibitor

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