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Levonorgestrel

Catalog No. T1263   CAS 797-63-7
Synonyms: D-Norgestrel
Purity 99.83% Datasheet MSDS

Levonorgestrel is a Progestin and Progestin-containing Intrauterine Device. The physiologic effect of levonorgestrel is by means of Inhibit Ovum Fertilization.

Levonorgestrel, CAS 797-63-7
Pack Size Availability Price/USD Quantity
10 mg In stock 28.00
25 mg In stock 34.00
50 mg In stock 45.00
100 mg In stock 59.00
200 mg In stock 70.00
500 mg In stock 87.00
1 mL * 10 mM (in DMSO) In stock 50.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Levonorgestrel is a Progestin and Progestin-containing Intrauterine Device. The physiologic effect of levonorgestrel is by means of Inhibit Ovum Fertilization.
Targets&IC50 ER,   SRD5A1,  

Description

Levonorgestrel is a Progestin and Progestin-containing Intrauterine Device. The physiologic effect of levonorgestrel is by means of Inhibit Ovum Fertilization.

Targets&IC50

ER

SRD5A1

In Vitro

Levonorgestrel在静脉中,增加环状AMP的水平,并抑制PMA诱导的蛋白激酶C的活化。Levonorgestrel在大鼠黄体细胞,抑制oLH,dibutyryl-cAMP和孕烯醇酮诱导的孕酮分泌。Levonorgestrel抑制高钾(K(+))溶液或佛波醇肉豆蔻酸酯乙酸酯(PMA)在胞外钙(Ca(2+))存在和不存在时引起的收缩。Levonorgestrel通过抑制钙离子进入和蛋白激酶C活化导致内皮依赖性舒张通。Levonorgestrel对雌激素诱导的垂体增重和高催乳素血症的抑制被米非司酮减弱,而氟硝丁酰胺不能阻断Levonorgestrel的效果。

In Vivo

Levonorgestrel引起雄性和雌性蟑螂编码黄体化激素β亚基(lhβ)的基因的mRNA表达显著上调,并抑制编码卵泡刺激素β亚基(fshβ)的基因的mRNA表达。Levonorgestrel下调长爪沙鼠的卵巢中卵泡刺激素受体、黄体生成素受体、卵巢雌激素受体β和孕激素受体的mRNA表达,以及子宫中ERα和PR的mRNA表达。

Synonyms D-Norgestrel
Purity 98.00%
Appearance solid
Molecular Weight 312.45
Formula C21H28O2
CAS No. 797-63-7

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 31.3 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Tellería CM, et al. J Steroid Biochem Mol Biol. 1994 Aug;50(3-4):161-6. 2. Herkert O, et al. Br J Pharmacol,2000, 130(8), 1911-1918. 3. Sala-Mateus C, et al. Enferm Infecc Microbiol Clin. 1991 Feb;9(2):117-8. 4. Lv XH, et al. Exp Anim,2011, 60(4), 363-371. 5. Kroupova HK, et al. Aquat Toxicol,2014, 154, 154-162.

Related Compound Libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Natural Compound Library for HTS Anti-cancer Compound Library Endocrinology-Hormones Library FDA-approved Drug Library GPCR Compound Library

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