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Licochalcone D

Catalog No. T4518 CAS 144506-15-0

Licochalcone D may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing apoptosis via the mitochondrial pathway and blocking cell migration and invasion. Licochalcone D has cardioprotective potential against myocardial ischemia/reperfusion injury in langendorff-perfused rat hearts. Licochalcone D has anti-inflammatory activity, it shows suppression ability of nitric oxide (NO) production. Licochalcone D has anti-allergic activity, it suppresses degranulation by decreasing the intracellular Ca2+ level and tyrosine phosphorylation of ERK in RBL-2H3 cells.

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Licochalcone D, CAS 144506-15-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 97.00
5 mg	In stock	$ 297.00
10 mg	In stock	$ 443.00
25 mg	In stock	$ 718.00
50 mg	In stock	$ 992.00
100 mg	In stock	$ 1,330.00
1 mL * 10 mM (in DMSO)	In stock	$ 327.00

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Purity: 99.03%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Source

Natural Products > Fabaceae > Glycyrrhiza

Molecular Weight	354.4
Formula	C21H22O5
CAS No.	144506-15-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.54 mg/mL (10 mM)

Ethanol: Soluble

References and Literature

1. Wang P, et al. Licochalcone C induces apoptosis via B-cell lymphoma 2 family proteins in T24 cells[J]. Molecular Medicine Reports, 2015, 12(5):7623. 2. Yuan X, et al. Cardioprotective Effect of Licochalcone D against Myocardial Ischemia/Reperfusion Injury in Langendorff-Perfused Rat Hearts[J]. Plos One, 2015, 10(6):e20128375. 3. Kim S J, et al. Synthesis of licochalcone analogues with increased anti-inflammatory activity[J]. Bioorganic & Medicinal Chemistry Letters, 2014, 24(1):181-185. 4. Tanifuji S, et al. Licochalcones suppress degranulation by decreasing the intracellular Ca2+ level and tyrosine phosphorylation of ERK in RBL-2H3 cells.[J]. International Immunopharmacology, 2010, 10(7):769-776.

Citations

1. Lu X, Ji Q, Pan H, et al.IL-23p19 deficiency reduces M1 macrophage polarization and improves stress-induced cardiac remodeling by alleviating macrophage ferroptosis in mice.Biochemical Pharmacology.2024: 116072.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Anti-Cancer Active Compound Library Inhibitor Library Antidepressant Compound Library Anti-Cancer Compound Library Anti-Obesity Compound Library Selected Plant-Sourced Compound Library Anti-Lung Cancer Compound Library Traditional Mongolian Medicine Compound Library Bioactive Compound Library

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Keywords

Licochalcone D 144506-15-0 MAPK NF-Κb NF-κB ERK Apoptosis A375 anti-cancer antioxidant Reactive Oxygen Species Nuclear factor-κB NF-κB p65 Nuclear factor-kappaB Inhibitor anti-inflammatory inhibit inhibitor

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