Home Tools

Lidocaine hydrochloride

Catalog No. T1144 CAS 73-78-9

Synonyms: Lidocaine HCL, Lignocaine hydrochloride, Xyloneural, Lidothesin

Lidocaine hydrochloride (Lignocaine hydrochloride) is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Lidocaine hydrochloride Chemical Structure

Lidocaine hydrochloride, CAS 73-78-9

Pack Size	Availability	Price/USD	Quantity
500 mg	In stock	$ 45.00

Bulk Inquiry

Select Batch

Purity: 100%

Purity: 99.83%

Purity: 99.81%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Lidocaine hydrochloride (Lignocaine hydrochloride) is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
In vitro	Lidocaine above 1.25 g/l reduces cellular viability and triggers apoptosis in HCE cells in a time- and dose-dependent manner. Lidocaine-induced apoptosis is caspase dependent and may be related to mitochondrial pathway[1]. Lidocaine, at the level of tissue concentration under topical or local administration, also has a direct inhibitory effect on the activity of epidermal growth factor receptor (EGFR), which is a potential target for antiproliferation in cancer cells[3].
In vivo	Intravenous administration of the local anaesthetic lidocaine has been used to treat neuropathic pain for several decades and significantly improves postoperative pain associated with complex spine surgery and cholecystectomy. It is well established that lidocaine used for regional anaesthesia blocks impulses in peripheral nerves by inhibiting voltage-gated sodium (Na+) channels. Intravenous lidocaine has an analgesic effect on mechanical noxious response, decreases the spinal noxious response induced by peripheral pinch stimuli and the frequency of spontaneous excitatory postsynaptic currents(EPSCs) without changing their amplitude. It has no effect on spontaneous inhibitory postsynaptic currents and produces an outward current in SG neurons[2].
Cell Research	Cells at logarithmic phase are treated with lidocaine hydrochloride at concentrations (w/v) from 10 to 0.15625 g/l in step dilutions. HCE cells without lidocaine treatment are used as controls. The morphology and growing status of the cells are monitored every 4 hr.(Only for Reference)

Synonyms	Lidocaine HCL, Lignocaine hydrochloride, Xyloneural, Lidothesin
Molecular Weight	270.798
Formula	C14H23ClN2O
CAS No.	73-78-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 49 mg/mL(180.9 mM)

Ethanol: 54 mg/mL (199.41 mM)

References and Literature

1. Yu HZ, et al. Basic Clin Pharmacol Toxicol. 2014, 114(4):352-9. 2. Kurabe M, et al. Sci Rep. 2016, 6:26253. 3. Sakaguchi M, et al. Anesth Analg. 2006, 102(4):1103-7. 4. Huang Z, Wei P, Gan L, et al. Protective effects of different anti‑inflammatory drugs on tracheal stenosis following injury and potential mechanisms[J]. Molecular Medicine Reports. 2021, 23(5): 1-11.

Citations

1. Huang Z, Wei P, Gan L, et al. Protective effects of different anti-inflammatory drugs on tracheal stenosis following injury and potential mechanisms. Molecular Medicine Reports. 2021, 23(5): 1-11

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library FDA-Approved Kinase Inhibitor Library EMA Approved Drug Library Kinase Inhibitor Library Anti-Cancer Drug Library Inhibitor Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library FDA-Approved & Pharmacopeia Drug Library Anti-Breast Cancer Compound Library

Related Products

Related compounds with same targets

MPTP hydrochloride Bioymifi CCI-007 L-Cystathionine Vorinostat Bax inhibitor peptide V5 acetate 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea Ganoderenic acid D

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step Two: Enter the in vivo formulation

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

Calculate Reset

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Calculator

Molarity Calculator

Dilution Calculator

Reconstitution Calculation

Molecular Weight Calculator

Mass

Concentration

Volume

Molecular Weight

Molarity Calculator allows you to calculate the

Mass of a compound required to prepare a solution of known volume and concentration
Volume of solution required to dissolve a compound of known mass to a desired concentration
Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

Concentration (Start)

Volume (Start)

Concentration (End)

Volume (End)

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Molecule Formula

Molecular Weight g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Lidocaine hydrochloride 73-78-9 Apoptosis MAPK Membrane transporter/Ion channel NF-Κb NF-κB MEK ERK Sodium Channel Extracellular signal regulated kinases Lidocaine Mitogen-activated protein kinase kinase Nuclear factor-kappaB Lidocaine HCL inhibit Na channels Na+ channels Lignocaine Hydrochloride MAPKK Lignocaine Nuclear factor-κB Lignocaine hydrochloride Inhibitor MAP2K Xyloneural Lidothesin Lidocaine Hydrochloride inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.