Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | Inquiry | |
50 mg | 8-10 weeks | Inquiry | |
100 mg | 8-10 weeks | Inquiry |
Description | Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity. |
In vitro | Litronesib (LY2523355) is a selective Eg5 inhibitor. Litronesib (25 nM) induces cancer cells to death during mitotic arrest, and this needs sustained activation of spindle-assembly checkpoint (SAC)[1]. |
In vivo | Litronesib (LY2523355; 1.1, 3.3, 10, and 30 mg/kg, i.v.) displays antitumor activity in a dose-dependently. It also leads to a dramatic increase in cancer cells immuno-positive for histone H3 phosphorylation in Colo205 xenograft tumors[1]. |
Synonyms | KF-89617, LY-2523355 |
Molecular Weight | 511.7 |
Formula | C23H37N5O4S2 |
CAS No. | 910634-41-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (97.71 mM)
You can also refer to dose conversion for different animals. More
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Litronesib 910634-41-2 Cytoskeletal Signaling Kinesin KF-89617 KF89617 LY-2523355 LY 2523355 LY2523355 KF 89617 inhibitor inhibit