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Lodelaben

Catalog No. T11865 CAS 111149-90-7

Synonyms: SC-39026, Declaben

Lodelaben is a human neutrophil elastase inhibitor with an IC50 and Ki of 0.5 and 1.5 μM, respectively.

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Lodelaben, CAS 111149-90-7

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

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Description	Lodelaben is a human neutrophil elastase inhibitor with an IC50 and Ki of 0.5 and 1.5 μM, respectively.
Targets&IC50	Elastase:(ki)1.5 μM , Elastase:0.5 μM
In vitro	Results indicate that the inhibition of human neutrophil elastase (HNE) by Lodelaben is non-competetive.?Lodelaben is not inhibitory at 10 μM with the synthetic substrates or at 5 μM vith Azocoll.?Pseudomonas aeruginosa elastase, a metallo-protease is not inhibited by Lodelaben.?Cathepsin G activity, however, is inhibited by Lodelaben, with an IC50 of approximately 2.5 μM, with Azocoll as substrate[1].
In vivo	The mean pulmonary artery pressures in both the saline/vehicle and saline/Lodelaben groups were comparable, at 16.4±1.1 and 17.4±0.9 mm Hg, respectively. However, the mean pressure significantly increased in the monocrotaline/vehicle group to 27.5±0.8 mm Hg. Notably, Lodelaben treatment in monocrotaline-administered rats markedly reduced the pressure to 21.00±1.6 mm Hg (p<0.05). In terms of vascular muscularization at the alveolar wall level, saline-treated rats, regardless of Lodelaben administration, demonstrated minimal muscularization (1.9±1.4% and 0.4±0.4%, respectively). Conversely, Lodelaben administration in monocrotaline-treated rats significantly lowered the percentage of muscularized alveolar wall arteries to 10.0±3.6%[2], indicating a protective effect of Lodelaben against monocrotaline-induced vascular alterations.

Synonyms	SC-39026, Declaben
Molecular Weight	425.04
Formula	C25H41ClO3
CAS No.	111149-90-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Nakao A, et al. SC-39026, a specific human neutrophil elastase inhibitor. Biochem Biophys Res Commun. 1987 Sep 15;147(2):666-74. 2. Ilkiw R, et al. SC-39026, a serine elastase inhibitor, prevents muscularization of peripheral arteries, suggesting a mechanism of monocrotaline-induced pulmonary hypertension in rats. Circ Res. 1989 Apr;64(4):814-25.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Lodelaben 111149-90-7 Others SC39026 SC-39026 Declaben SC 39026 inhibitor inhibit

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