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Lornoxicam

Catalog No. T1468 CAS 70374-39-9

Synonyms: Ro 13-9297, Chlortenoxicam, TS110

Lornoxicam (Chlortenoxicam) (chlortenoxicam) is a new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory, and antipyretic properties. Lornoxicam differs from other oxicam compounds in its potent inhibition of prostaglandin biosynthesis, a property that explains the particularly pronounced efficacy of the drug. Lornoxicam is approved for use in Japan.

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Lornoxicam, CAS 70374-39-9

Pack Size	Availability	Price/USD
50 mg	In stock	$ 44.00
100 mg	In stock	$ 63.00
200 mg	In stock	$ 107.00
500 mg	In stock	$ 177.00
1 mL * 10 mM (in DMSO)	In stock	$ 68.00

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Purity: 99.53%

Purity: 99.41%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Lornoxicam (Chlortenoxicam) (chlortenoxicam) is a new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory, and antipyretic properties. Lornoxicam differs from other oxicam compounds in its potent inhibition of prostaglandin biosynthesis, a property that explains the particularly pronounced efficacy of the drug. Lornoxicam is approved for use in Japan.
Targets&IC50	COX-2:8 nM, COX-1:5 nM
In vitro	Lornoxicam is as effective as the opioid analgesics morphine, pethidine (meperidine) and tramadol in relieving postoperative pain following gynaecological or orthopaedic surgery, and as effective as other NSAIDs after oral surgery. Lornoxicam is also as effective as other NSAIDs in relieving symptoms of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute sciatica and low back pain. [1]
In vivo	Lornoxicam dose relatedly reduces the total number of c-Fos-LI neurons with the strongest effect corresponding to the 75% reduction for the highest dose of 9 mg/kg, and the 45% reduction for the low dose of 0.3 mg/kg. Lornoxicam (0.1, 0.3 mg/kg, 1 mg/kg, 3 mg/kg and 9 mg/kg, i.v.) significantly reduces the number of c-Fos-LI neurons in both superficial (24%, 33%, 53%, 54%, and 63% reduction, respectively) and deep (28%, 48%, 62%, 69% and 79% reduction, respectively) laminae of the dorsal horn of the spinal cord. [2] Lornoxicam reduces hyperalgesia with an effective dose that provides 50% inhibition (ED50) of 0.083 mg/kg, 3.9 mg/kg and 4.3 mg/kg respectively in a chronic rat model of arthritis. Lornoxicam significantly reduces the PGE2 level in paw exudate and the cerebrospinal fluid in rats. Lornoxicam 0.16 mg/kg, celecoxib 4 mg/kg and loxoprofen 2.4 mg/kg significantly reduces hyperalgesia to a similar extent in acute oedematous rats. [3]

Synonyms	Ro 13-9297, Chlortenoxicam, TS110
Molecular Weight	371.82
Formula	C13H10ClN3O4S2
CAS No.	70374-39-9

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (26.9 mM)

References and Literature

1. Balfour JA, et al. Drugs,1996, 51(4), 639-657. 2. Buritova J, et al. Inflammopharmacology,1997, 5(4), 331-341. 3. Futaki N, et al. J Pharm Pharmacol,2009, 61(5), 607-614. 4. Berg J, et al. Inflamm Res. 1999, 48(7):369-79.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Inhibitor Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Drug Library ReFRAME Related Library Human Metabolite Library HIF-1 Signaling Pathway Compound Library Anti-Pancreatic Cancer Compound Library

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Keywords

Lornoxicam 70374-39-9 Immunology/Inflammation Metabolism Neuroscience Endogenous Metabolite COX Ro 13-9297 Cyclooxygenase inhibit TS 110 Chlortenoxicam Inhibitor TS110 TS-110 inhibitor

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