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Lumasiran

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Catalog No. T39273Cas No. 1834610-13-7
Alias ALN-G01

Lumasiran (ALN-G01), a siRNAproduct, targets glycolate oxidase to inhibit hepatic oxalate production. By silencing the gene encoding glycolate oxidase, Lumasiran depletes the enzyme, preventing the synthesis of oxalate, a toxic metabolite directly linked to the clinical manifestations of Primary hyperoxaluria type 1 (PH1).

Lumasiran

Lumasiran

😃Good
Catalog No. T39273Alias ALN-G01Cas No. 1834610-13-7
Lumasiran (ALN-G01), a siRNAproduct, targets glycolate oxidase to inhibit hepatic oxalate production. By silencing the gene encoding glycolate oxidase, Lumasiran depletes the enzyme, preventing the synthesis of oxalate, a toxic metabolite directly linked to the clinical manifestations of Primary hyperoxaluria type 1 (PH1).
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1 mg$813Backorder
5 mg$1,990Backorder
10 mg$3,230Backorder
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Product Introduction

Bioactivity
Description
Lumasiran (ALN-G01), a siRNAproduct, targets glycolate oxidase to inhibit hepatic oxalate production. By silencing the gene encoding glycolate oxidase, Lumasiran depletes the enzyme, preventing the synthesis of oxalate, a toxic metabolite directly linked to the clinical manifestations of Primary hyperoxaluria type 1 (PH1).
In vitro
Lumasiran effectively decreased the excretion of urinary oxalate, which is responsible for the progression of kidney failure in patients with Primary Hyperoxaluria Type 1 (PH1)[1].
In vivo
Lumasiran sodium is a subcutaneously administered, liver-directed RNA interference (RNAi) therapeutic agent[2].
AliasALN-G01
Chemical Properties
Cas No.1834610-13-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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