store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MAFP (Methyl Arachidonyl Fluorophosphonate) is an effective irreversible inhibitor of anandamide amidase. MAFP is an active-site directed and irreversible inhibitor of cPLA2 and iPLA2.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 98.00 | |
25 mg | 10-14 weeks | $ 719.00 | |
50 mg | 10-14 weeks | $ 934.00 | |
100 mg | 10-14 weeks | $ 1,490.00 |
Description | MAFP (Methyl Arachidonyl Fluorophosphonate) is an effective irreversible inhibitor of anandamide amidase. MAFP is an active-site directed and irreversible inhibitor of cPLA2 and iPLA2. |
In vitro | In a concentration-dependent manner after a 5 min preincubation at 40°C in P388D1 cells, MAFP inhibits iPLA2 (IC50: 5 μM). MAFP is also an inhibitor of anandamide amidase and as a ligand for the CB1 cannabinoid receptor. MAFP shows selectivity towards anandamide amidase for which it is approximately 3000 and 30000-fold more potent than it is towards chymotrypsin and trypsin, respectively. cPLA is a phospholipid hydrolase using the hydroxyl of serine-228 residue as its catalytic nucleophile[1]. MAFP displaces [3H]CP-55940 binding to the CB1 cannabinoid receptor with an IC50 of 20 nM vs 40 nM for anandamide[2]. |
Synonyms | Methyl Arachidonyl Fluorophosphonate |
Molecular Weight | 370.48 |
Formula | C21H36FO2P |
CAS No. | 188404-10-6 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Methyl Acetate: 9.0 mg/mL (24.3 mM)
DMSO: 90.0 mg/mL (242.9 mM)
You can also refer to dose conversion for different animals. More
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MAFP 188404-10-6 Metabolism Phospholipase Methyl Arachidonyl Fluorophosphonate inhibitor inhibit