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MAK683

Catalog No. T15201 CAS 1951408-58-4

Synonyms: inhibit, MAK683, MAK-683, Inhibitor, Histone Methyltransferase, MAK 683

MAK683 is an inhibitor of embryonic ectoderm development (EED) (IC50s: 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay).

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MAK683, CAS 1951408-58-4

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	MAK683 is an inhibitor of embryonic ectoderm development (EED) (IC50s: 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay).
Targets&IC50	EED Alphascreen:59 nM, LC-MS:89 nM, ELISA:26 nM
In vitro	After treatment 14 days, MAK683 has antiproliferative activities in B cell lymphoma cell KARPAS422 (IC50: 30 nM) [1].

Synonyms	inhibit, MAK683, MAK-683, Inhibitor, Histone Methyltransferase, MAK 683
Molecular Weight	376.39
Formula	C20H17FN6O
CAS No.	1951408-58-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 50 mg/mL (132.84 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Chan, Ho Man, et al. TRIAZOLOPYRIMIDINE COMPOUNDS AND USES THEREOF. US20160176882 A1. 2. Huang D, et al. Binding Modes of Small-Molecule Inhibitors to the EED Pocket of PRC2. Chemphyschem. 2020 Feb 4;21(3):263-271.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Bioactive Compound Library Clinical Compound Library

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.