Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MCB-613 is an effective steroid receptor coactivator (SRC) stimulator.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 38.00 | |
2 mg | In stock | $ 54.00 | |
5 mg | In stock | $ 89.00 | |
10 mg | In stock | $ 147.00 | |
25 mg | In stock | $ 272.00 | |
50 mg | In stock | $ 397.00 | |
100 mg | In stock | $ 597.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 97.00 |
Description | MCB-613 is an effective steroid receptor coactivator (SRC) stimulator. |
In vitro | MCB-613 selectively and reversibly binds to the RID of SRC-3, and selectively kills cancer cells including MCF-7 (breast), PC-3 (prostate), H1299 (lung), and HepG2 (liver) cells, without toxicity to mouse primary hepatocytes and mouse embryonic fibroblasts (MEFs). MCB-613 also increases SRCs' interactions with other coactivators and markedly induces ER stress coupled to the generation of reactive oxygen species (ROS). [1] |
In vivo | In an MCF-7 breast cancer mouse xenograft model, MCB-613 (20 mg/kg, i.p.) significantly and dramatically inhibits the growth of the tumor while causing no obvious animal toxicity and body weight less. [1] |
Kinase Assay | Luciferase assays: After various compound treatments, cells are lysed in luciferase lysis buffer and assayed for luciferase activity using the ONE-Glo luciferase assay system. All luciferase activities are normalized to protein concentration determined by Bradford assay. |
Cell Research | Cells are seeded in 96-well plates and allowed to reach 60% to 70% confluence. After indicated compound treatments, relative numbers of viable cells are measured by MTS assay using the Cell Titer 96 Aqueous One Solution Cell Proliferation Assay.(Only for Reference) |
Synonyms | MCB 613 |
Molecular Weight | 304.39 |
Formula | C20H20N2O |
CAS No. | 1162656-22-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 56 mg/mL (184 mM)
DMSO: 56 mg/mL (184 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
MCB-613 1162656-22-5 Angiogenesis Tyrosine Kinase/Adaptors Src inhibit Inhibitor MCB613 MCB 613 inhibitor