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MK2-IN-1 hydrochloride

Catalog No. T4442 CAS 1314118-94-9

Synonyms: MK2 Inhibitor, MK 25

MK2-IN-1 hydrochloride (MK 25) is a highly selective, non-ATP competitive inhibitor of p38/mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2 or MK2, IC50: 0.11 μM) [1].

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MK2-IN-1 hydrochloride Chemical Structure

MK2-IN-1 hydrochloride, CAS 1314118-94-9

Pack Size	Availability	Price/USD
2 mg	In stock	$ 32.00
5 mg	In stock	$ 51.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 196.00
50 mg	In stock	$ 353.00
100 mg	In stock	$ 522.00
1 mL * 10 mM (in DMSO)	In stock	$ 58.00

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Purity: 99.67%

Biological Description

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Storage & Solubility Information

Description	MK2-IN-1 hydrochloride (MK 25) is a highly selective, non-ATP competitive inhibitor of p38/mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2 or MK2, IC50: 0.11 μM) [1].
Targets&IC50	MK2:0.11 Μm
In vitro	MK2-IN-1 has been shown to inhibit pro-inflammatory cytokine secretion from the human THP-1 acute monocytic leukemia cell line, causing inhibition of LPS-stimulated TNF-α (IC50: 4.4 μM) and IL-6 (IC50: 5.2 μM) secretion.1 It can also inhibit IL-1β-stimulated matrix-metalloprotease 13 secretion from the SW1353 chondrosarcoma cell line (IC50: 5.7 μM) and human primary chondrocyte cultures (IC50: 2.2 μM) [1].

Synonyms	MK2 Inhibitor, MK 25
Molecular Weight	509.43
Formula	C27H26Cl2N4O2
CAS No.	1314118-94-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (98.15 mM)

H2O: Insoluble

References and Literature

1. Huang X, Shipps Jr G W, Cheng C C, et al. Discovery and hit-to-lead optimization of non-ATP competitive MK2 (MAPKAPK2) inhibitors[J]. ACS medicinal chemistry letters, 2011, 2(8): 632-637.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Kinase Inhibitor Library Anti-Cancer Compound Library Nonsteroidal Anti-Inflammatory Compound Library Anti-Liver Cancer Compound Library Anti-Prostate Cancer Compound Library Immunology/Inflammation Compound Library HIF-1 Signaling Pathway Compound Library MAPK Inhibitor Library Neural Regeneration Compound Library

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Related compounds with same targets

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MK2-IN-1 hydrochloride 1314118-94-9 MAPK MK2-IN-1 Hydrochloride MK2 Inhibitor inhibit MK25 MAP kinase activated protein kinase 2 MAPK activated protein kinase 2 MK 25 MAPKAPK2 (MK2) Inhibitor MK2IN1 hydrochloride MK2 IN 1 hydrochloride MAPKAP kinase 2 MK-25 MK-2-IN-1 hydrochloride Mitogen-activated protein kinase activated protein kinase 2 inhibitor

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