Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ML-00253764 hydrochloride is an antagonist of nonpeptidic melanocortin receptor 4 (MC4R) (Ki and IC50 of 0.16 μM and 0.103 μM, respectively).
Description | ML-00253764 hydrochloride is an antagonist of nonpeptidic melanocortin receptor 4 (MC4R) (Ki and IC50 of 0.16 μM and 0.103 μM, respectively). |
Targets&IC50 | MC4R:0.103 µM (IC50) |
In vitro | ML-00253764 (100 μM) decreases cAMP production induced by [NLE4,D-Phe7]-α-melanocyte stimulating hormone ([NDP]-α-MSH) by 20% in MC4R-expressing HEK293 cell membranes, but has no effect on cAMP levels in MC3R- or MC5R-expressing membranes[1]. |
In vivo | ML-00253764 shows protection against tumor-induced body weight loss upon chronic, peripheral dosing in CT-26 tumor bearing BALB/c mice[1]. |
Molecular Weight | 413.71 |
Formula | C18H19BrClFN2O |
CAS No. | 1706524-94-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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ML-00253764 hydrochloride 1706524-94-8 Others ML-00253764 Hydrochloride ML00253764 hydrochloride ML 00253764 hydrochloride ML 00253764 Hydrochloride ML00253764 Hydrochloride inhibitor inhibit