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ML417

Catalog No. T8423 CAS 1386162-69-1

ML417 is a selective and brain penetrant agonist of D3 Dopamine (EC50 : 38 nM).

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ML417, CAS 1386162-69-1

Pack Size	Availability	Price/USD
2 mg	In stock	$ 34.00
5 mg	In stock	$ 55.00
10 mg	In stock	$ 98.00
25 mg	In stock	$ 193.00
50 mg	In stock	$ 355.00
100 mg	In stock	$ 527.00
1 mL * 10 mM (in DMSO)	In stock	$ 82.00

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Purity: 99.88%

Biological Description

Chemical Properties

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Description	ML417 is a selective and brain penetrant agonist of D3 Dopamine (EC50 : 38 nM).
Targets&IC50	D3:38 nM(EC50)
In vitro	Molecular modeling suggests that ML417 interacts with the D3R in a unique manner, possibly explaining its remarkable selectivity.?ML417 was also found to protect against neurodegeneration of dopaminergic neurons derived from iPSCs.?Together with promising pharmacokinetics and toxicology profiles, these results suggest that ML417 is a novel and uniquely selective D3R agonist that may serve as both a research tool and a therapeutic lead for the treatment of neuropsychiatric disorders.

Molecular Weight	379.45
Formula	C22H25N3O3
CAS No.	1386162-69-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (131.77 mM), Sonification is recommended.

References and Literature

1. Moritz AE, et al. Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist. J Med Chem. 2020;63(10):5526‐5567.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library GPCR Compound Library Bioactive Compound Library Bioactive Compounds Library Max Neuronal Signaling Compound Library NO PAINS Compound Library Neurotransmitter Receptor Compound Library Anti-Parkinson's Disease Compound Library Antidepressant Compound Library CNS-Penetrant Compound Library

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Keywords

ML417 1386162-69-1 GPCR/G Protein Neuroscience Dopamine Receptor Arrestin neuroprotection dopaminergic β-arrestin translocation phosphorylation ML-417 ML 417 neurons Inhibitor inhibit inhibitor

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