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MLT-943

Catalog No. T9216 CAS 1832576-04-1

Synonyms: MLT943

MLT-943 is a potent, selective and orally active MALT1 protease inhibitor. [1].

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

MLT-943, CAS 1832576-04-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 123.00
5 mg	In stock	$ 263.00
10 mg	In stock	$ 396.00
25 mg	In stock	$ 663.00
50 mg	In stock	$ 945.00
100 mg	In stock	$ 1,280.00
500 mg	In stock	$ 2,570.00
1 mL * 10 mM (in DMSO)	In stock	$ 288.00

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Purity: 99.82%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	MLT-943 is a potent, selective and orally active MALT1 protease inhibitor. [1].
In vitro	MLT-943 inhibits stimulated-IL-2 secretion in PBMC or in whole blood with a similar?IC50?across species (0.07-0.09 μM in PBMC, 0.6-0.8 μM in whole blood).

Synonyms	MLT943
Molecular Weight	414.77
Formula	C16H14ClF3N6O2
CAS No.	1832576-04-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 247 mg/mL (595.51 mM), Sonication is recommended.

References and Literature

1. Kea Martin, et al. Pharmacological Inhibition of MALT1 Protease Leads to a Progressive IPEX-Like Pathology. Front Immunol 2. Jean Quancard, et al. Optimization of the In Vivo Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood. J Med Chem. 2020 Dec 10;63(23):14594-14608.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library NF-κB Signaling Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Immunology/Inflammation Compound Library Orally Active Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

JNJ-67856633 Mepazine MIR96-IN-1 MALT1 inhibitor MI-2

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MLT-943 1832576-04-1 Immunology/Inflammation MALT inflammation MLT943 paw swelling MALT1 inhibit MLT 943 Inhibitor mucosa associated lymphoid tissue lymphoma translocation gene 1 anti-inflammatory inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.