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MM 11253

Catalog No. T23005   CAS 345952-44-5
Synonyms: MM-11253

MM 11253 is a RARγ antagonist with IC50 of 44nM.

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MM 11253 Chemical Structure
MM 11253, CAS 345952-44-5
Pack Size Availability Price/USD Quantity
1 mg In stock $ 34.00
5 mg In stock $ 80.00
10 mg In stock $ 128.00
25 mg In stock $ 289.00
50 mg In stock $ 455.00
100 mg In stock $ 672.00
1 mL * 10 mM (in DMSO) In stock $ 82.00
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Purity: 98.62%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description MM 11253 is a RARγ antagonist with IC50 of 44nM.
Targets&IC50 RARγ:44 nM (IC50), RXRα:>1000 nM (IC50), RARα:1000 nM (IC50), RARβ:>1000 nM (IC50)
In vitro MM11253 blocks the ability of MM11254 and MM11389 to inhibit squamous cell carcinoma cell growth [2].
Synonyms MM-11253
Molecular Weight 462.67
Formula C28H30O2S2
CAS No. 345952-44-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (216.1 mM), sonification is recommended.

TargetMolReferences and Literature

1. M I Dawson, et al. Retinoic acid (RA) receptor transcriptional activation correlates with inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase (ODC) activity by retinoids: a potential role for trans-RA-induced ZBP-89 in ODC inhibition. Int J Cancer. 2001 Jan 1;91(1):8-21. 2. Q Le, et al. Modulation of retinoic acid receptor function alters the growth inhibitory response of oral SCC cells to retinoids. Oncogene. 2000 Mar 9;19(11):1457-65.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max Inhibitor Library Neuronal Differentiation Compound Library Nuclear Receptor Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets
Mofarotene MSU-42011 AR7 AC-261066 Peretinoin BMS641 WYC-209 Retinoic acid

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Keywords

MM 11253 345952-44-5 Metabolism Retinoid Receptor MM11253 MM-11253 inhibitor inhibit

 

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