Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MRZ 2-514 (8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one) is a strychnine-insensitive modulatory site of the NMDA receptor (glycineB)antagonist with Ki of 33 μM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 347.00 | |
5 mg | In stock | $ 738.00 | |
10 mg | In stock | $ 995.00 | |
25 mg | In stock | $ 1,630.00 | |
50 mg | In stock | $ 2,190.00 | |
100 mg | In stock | $ 2,980.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 685.00 |
Description | MRZ 2-514 (8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one) is a strychnine-insensitive modulatory site of the NMDA receptor (glycineB)antagonist with Ki of 33 μM. |
Targets&IC50 | AMPA:72.7 μM, NMDA:33 μM (Ki) |
In vitro | MRZ 2-514 against peak AMPA-induced currents with IC50 values of 72.7 μM[1]. |
In vivo | In mice, MRZ 2-514 has anticonvulsive action in the MES model, and the effect is prolonged by probenecid[1]. |
Synonyms | 8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one |
Molecular Weight | 308.09 |
Formula | C11H6BrN3O3 |
CAS No. | 202808-11-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 18.33 mg/ml (59.51 mM)
You can also refer to dose conversion for different animals. More
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MRZ 2-514 202808-11-5 Neuroscience NMDAR inhibit Inhibitor MRZ 2514 MRZ 2 514 iGluR Ionotropic glutamate receptors 8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one inhibitor