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MW-150

Catalog No. T5494 CAS 1628502-91-9

Synonyms: MW01-18-150SRM

MW-150 (MW01-18-150SRM) is a unique protein kinase inhibitor, is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM.

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MW-150, CAS 1628502-91-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 33.00
5 mg	In stock	$ 97.00
10 mg	In stock	$ 155.00
25 mg	In stock	$ 322.00
50 mg	In stock	$ 478.00
100 mg	In stock	$ 689.00
500 mg	In stock	$ 1,480.00
1 mL * 10 mM (in DMSO)	In stock	$ 116.00

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Purity: 99.32%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	MW-150 (MW01-18-150SRM) is a unique protein kinase inhibitor, is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM.
Targets&IC50	p38α:101 nM (Ki)
In vitro	MW-150 treatment blocked in a concentration-dependent manner the increased IL-1β production by activated glia. The IC50?values for these MW150 cellular activities are 332 nM (MK2) and 936 nM (IL-1β), values which are consistent with the in vitro?Ki?of 101 nM for p38αMAPK.
Animal Research	MW-150 (2.5 mg/kg; given i.p.; daily for 14 days) treatment in APPNLh/NLh × PSP264L/P264L knock-in mouse (with no overexpression of the amyloid precursor protein) exhibits RAWM behavior indistinguishable from WT mice

Synonyms	MW01-18-150SRM
Molecular Weight	381.47
Formula	C24H23N5
CAS No.	1628502-91-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 6.25 mg/mL (16.38 mM), Sonication is recommended.

References and Literature

1. Roy SM, et al. Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models. ACS Chem Neurosci. 2015 Apr 15;6(4):666-80.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Inhibitor Library Osteogenesis Compound Library Neural Regeneration Compound Library Anti-Colorectal Cancer Compound Library Bioactive Compounds Library Max CNS-Penetrant Compound Library HIF-1 Signaling Pathway Compound Library Reprogramming Compound Library Apoptosis Compound Library

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Keywords

MW-150 1628502-91-9 Autophagy MAPK p38 MAPK inhibit Inhibitor MW01-18-150SRM MW150 MW 150 inhibitor

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