Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MYCi975 (NUCC-0200975) is an orally active inhibitor of MYC.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 127.00 | |
5 mg | In stock | $ 297.00 | |
10 mg | In stock | $ 492.00 | |
25 mg | In stock | $ 819.00 | |
50 mg | In stock | $ 1,130.00 | |
100 mg | In stock | $ 1,530.00 | |
500 mg | In stock | $ 2,970.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 383.00 |
Description | MYCi975 (NUCC-0200975) is an orally active inhibitor of MYC. |
In vitro | MYCi975 inhibits P493-6, MV411,SK-N-B2 cells viability in an MYC-dependent manner(IC50s of 3.7, 3.9, 6.4 μM, respectively)[1]. |
In vivo | The initial lead, MYC inhibitor 361 (MYCi361), suppressed in vivo tumor growth in mice, increased tumor immune cell infiltration, upregulated PD-L1 on tumors, and sensitized tumors to anti-PD1 immunotherapy. However, 361 demonstrated a narrow therapeutic index. An improved analog, MYCi975 showed better tolerability. |
Synonyms | NUCC-0200975 |
Molecular Weight | 561.3 |
Formula | C25H16Cl2F6N2O2 |
CAS No. | 2289691-01-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 247 mg/mL (440.05mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
MYCi975 2289691-01-4 Cell Cycle/Checkpoint c-Myc NUCC 0200975 NUCC0200975 MYCi-975 NUCC-0200975 inhibitor inhibit