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Magainin 2

Catalog No. TP1444 CAS 108433-95-0

Magainin II is a member of the antimicrobial peptides family

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Magainin 2, CAS 108433-95-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 157.00
5 mg	In stock	$ 392.00
10 mg	In stock	$ 583.00
25 mg	In stock	$ 933.00
50 mg	In stock	$ 1,270.00
100 mg	In stock	$ 1,690.00

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Purity: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Magainin II is a member of the antimicrobial peptides family

In vitro

Magainin 2 exhibits bactericidal activity by permeabilizing cell membranes and inducing early apoptosis-like morphological changes in Escherichia coli. It enhances the expression of a bacterial protein with caspase substrate affinity and modulates RecA expression, akin to caspase-like proteins. Notably, it disrupts membranes without significant harm to mammalian cells, targeting primarily the lipid matrix. In Paramecium caudatum, a protozoan, magainin 2 at 10 μg/mL induces osmotic swelling and cell burst by interfering with membrane functions crucial for osmotic regulation. Its mechanism differs in bacterial and mammalian cells; it forms approximately 2.8 nm pores in B. megaterium membranes and crosses into the cytosol, whereas in CHO-K1 cells, it causes significant membrane disturbance, allowing entry of molecules larger than 23 nm, and results in membrane budding and lipid redistribution, notably affecting mitochondria and nuclei.

Molecular Weight	2466.9
Formula	C114H180N30O29S
CAS No.	108433-95-0

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mM

References and Literature

1. Lee W, et al. Magainin 2 induces bacterial cell death showing apoptotic properties. Curr Microbiol. 2014 Dec;69(6):794-801.

Related compound libraries

This product is contained In the following compound libraries：

Antiparasitic Natural Product Library Peptide Compound Library Antibiotics Library Anti-infective Natural Product Library Anti-Fungal Compound Library Natural Product Library for HTS Natural Product Library Anti-Infection Compound Library NO PAINS Compound Library

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Keywords

Magainin 2 108433-95-0 Microbiology/Virology Antibacterial Antibiotic Antifungal protozoa cytotoxicity Bacterial AMP phospholipid Inhibitor bacteria antimicrobial peptide Magainin2 gram-negative Magainin-2 cell gram-positive Magainin II inhibit Fungal inhibitor

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