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Manidipine

Catalog No. T6577 CAS 89226-50-6

Synonyms: Iperten, Franidipine, Artedil

Manidipine (Iperten), a calcium channel blocker, which is dihydropyridine type. It is utilized

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Manidipine, CAS 89226-50-6

Pack Size	Availability	Price/USD
10 mg	In stock	$ 38.00
25 mg	In stock	$ 54.00
50 mg	In stock	$ 88.00
100 mg	In stock	$ 162.00
200 mg	In stock	$ 233.00
500 mg	In stock	$ 393.00
1 mL * 10 mM (in DMSO)	In stock	$ 94.00

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Purity: 100%

Biological Description

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Description	Manidipine (Iperten), a calcium channel blocker, which is dihydropyridine type. It is utilized
Targets&IC50	Ca2+ channel:2.6 nM
In vitro	Manidipine, a Ca(2+)-channel blocker, at concentrations that lower elevated blood pressure, modulates the transcription rates of cytokine genes in the mesangial cells of humans that had been stimulated with platelet-derived growth factor BB isomer. [1] Manidipine inhibits the ET-1-induced [Ca2+]i increase by reducing both the transient and sustained Ca2+ increments in A7r5 cells and glomerular mesangial cells (MCs). Manidipine (10(-5) mol/L) potentiates ET-1-induced c-fos and c-jun expression in A7r5 cells. Manidipine is a potent inhibitor for ET-1-induced [Ca2+]i signaling and that Manidipine has multiple effects on ET-1-induced signaling, including potentiating the immediate-early gene response. [2]
In vivo	Manidipine reduces systolic blood pressure with a slight sympathetic reflex increase in heart rate, and increases plasma nitrite/nitrates in perfused rat heart from ischemia-reperfusion damage. Manidipine combined with Simvastatin reduces creatine kinase, lactate dehydrogenase and tumor necrosis factor-alpha, and enhancement of 6-keto-PGF(1alpha) during reperfusion. [3] Manidipine hydrochloride prevents isoproterenol-induced left ventricular hypertrophy and expression of mRNA of ANP, collagen types I and type III, and fibronectin in rats with isoproterenol-induced cardiac hypertrophy. [4] Manidipine HCl increases renal blood flow (RBF) by dilating the afferent arterioles and improves glomerular hypertension by dilating the efferent arterioles in hypertensive rats. [5]

Synonyms	Iperten, Franidipine, Artedil
Molecular Weight	610.7
Formula	C35H38N4O6
CAS No.	89226-50-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 113 mg/mL (185 mM)

Ethanol: 3 mg/mL (4.91 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Roth M, et al. Proc Natl Acad Sci U S A, 1992, 89(9), 4071-4075. 2. Huang S, et al. Am Heart J, 1993, 125(2 Pt 2), 589-597. 3. Rossoni G, et al. Eur J Pharmacol, 2008, 587(1-3), 224-230. 4. Yoshiyama M, et al. Jpn Circ J, 1998, 62(1), 47-52. 5. Tojo A, et al. J Cardiovasc Pharmacol, 1992, 20(6), 895-899.

Citations

1. Zhang R, Zhou J, Yan H, et al.Manidipine is not a potential inhibitor against SARS-CoV-2 main protease.Antimicrobial Agents and Chemotherapy.2024: e01297-23.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library FDA-Approved & Pharmacopeia Drug Library Metabolism Compound Library Human Metabolite Library Anti-Cardiovascular Disease Compound Library Target-Focused Phenotypic Screening Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Manidipine 89226-50-6 Membrane transporter/Ion channel Metabolism Calcium Channel Inhibitor inhibit Ca channels Iperten Ca2+ channels Franidipine Artedil inhibitor

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