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Mavacoxib

Catalog No. T7670   CAS 170569-88-7

Mavacoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) ,with Anti-Tumour activity.

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Mavacoxib Chemical Structure
Mavacoxib, CAS 170569-88-7
Pack Size Availability Price/USD Quantity
2 mg In stock $ 30.00
5 mg In stock $ 47.00
10 mg In stock $ 76.00
25 mg In stock $ 147.00
50 mg In stock $ 228.00
100 mg In stock $ 343.00
1 mL * 10 mM (in DMSO) In stock $ 52.00
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Purity: 99.36%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Mavacoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) ,with Anti-Tumour activity.
In vitro Mavacoxib is cytotoxic to a panel of human and canine osteosarcoma, mammary and bladder carcinoma cancer cell lines;?that it can induce apoptosis and inhibit the migration of these cells.?Mavacoxib can exert these effects independently of elevated COX-2 expression[1].Mavacoxib has a direct cell killing effect on cancer cells, increases apoptosis in cancer cells in a manner that may be independent of caspase activity, and has an inhibitory effect on cell migration.?Importantly, that cancer stem cells derived from osteosarcoma cell lines are sensitive to the cytotoxic effect of mavacoxib[2]
Molecular Weight 385.34
Formula C16H11F4N3O2S
CAS No. 170569-88-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5 mg/mL (58.39 mM)

TargetMolReferences and Literature

1. Emma A Hurst, Lisa Y Pang, David J Argyle .The Selective cyclooxygenase-2 Inhibitor Mavacoxib (Trocoxil) Exerts Anti-Tumour Effects in Vitro Independent of cyclooxygenase-2 Expression Levels[J].Vet Comp Oncol, 17 (2), 194-207 Jun 2019 2. Pang L Y , Argyle S A , Kamida A , et al. The long-acting COX-2 inhibitor mavacoxib (Trocoxil?) has anti-proliferative and pro-apoptotic effects on canine cancer cell lines and cancer stem cells in vitro[J]. BMC Veterinary Research, 2014, 10(1):184.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Human Metabolite Library Angiogenesis related Compound Library Anti-Aging Compound Library Neuronal Signaling Compound Library Anti-Cancer Compound Library Anti-Cardiovascular Disease Compound Library Nonsteroidal Anti-Inflammatory Compound Library Inhibitor Library NO PAINS Compound Library

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Keywords

Mavacoxib 170569-88-7 Immunology/Inflammation Neuroscience COX Cyclooxygenase Inhibitor inhibit inhibitor

 

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