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Mavorixafor

Catalog No. TQ0174 CAS 558447-26-0

Synonyms: AMD-070

Mavorixafor (AMD-070) is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding. Mavorixafor inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells (IC50 = 1 nM) and PBMCs (IC50 = 9 nM).

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Mavorixafor, CAS 558447-26-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 64.00
2 mg	In stock	$ 93.00
5 mg	In stock	$ 155.00
10 mg	In stock	$ 232.00
25 mg	In stock	$ 417.00
50 mg	In stock	$ 619.00
100 mg	In stock	$ 879.00
1 mL * 10 mM (in DMSO)	In stock	$ 262.00

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Description	Mavorixafor (AMD-070) is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding. Mavorixafor inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells (IC50 = 1 nM) and PBMCs (IC50 = 9 nM).
Targets&IC50	HIV-1 (NL4.3 strain):1 nM (in MT-4 cells), HIV-1 (NL4.3 strain):3 nM (in MT-4 cells), HIV-1 (NL4.3 strain):9 nM (in PBMCs), [125I]-SDF-CXCR4:13 nM
In vitro	Mavorixafor (6.6 µM) significantly decreases the anchorage-dependent growth, migration, and matrigel invasion of the B88-SDF-1 cells [1]. Mavorixafor shows no effect on other chemokine receptors (CCR1, CCR2b, CCR4, CCR5, CXCR1, and CXCR2) [2].
In vivo	AMD-070 (2 mg/kg, p.o.) markedly decreases the quantity of metastatic lung nodules in mice and reduces human Alu DNA expression without causing weight loss [1].
Cell Research	Cells are seeded on a 96-well plate at 5 × 10^3 cells/well in DMEM containing 10% FCS. Twenty-four hours later, the cells are treated with or without 2 µM AMD3100 or 6.6 µM AMD-070. After 24 or 48 h, the number of cells is quantified by an assay using MTT [2].
Animal Research	BALB/c nude mice are maintained under pathogen-free conditions. The experiments are initiated when the mice are 8 weeks of age. Briefly, the cells are inoculated into the blood vessels of nude mice (1× 10^6). These mice are sacrificed at day 49. The presence or absence of distant metastases is confirmed by hematoxylin and eosin (H&E) staining. For experimental chemotherapy, the mice are treated by the daily oral administration of 0.2 mL of saline for a vehicle or the same volume of AMD-070 (2 mg/kg) [2].

Synonyms	AMD-070
Molecular Weight	349.47
Formula	C21H27N5
CAS No.	558447-26-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 44 mg/mL (125.9 mM)

H2O: 7 mg/mL (20.03 mM), Heating is recommended.

DMSO: 17 mg/mL (48.64 mM)

References and Literature

1. Chow LN, et al. Impact of a CXCL12/CXCR4 Antagonist in Bleomycin (BLM) Induced Pulmonary Fibrosis and Carbon Tetrachloride (CCl4) Induced Hepatic Fibrosis in Mice. PLoS One. 2016 Mar 21;11(3):e0151765. 2. Skerlj RT, et al. Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication. J Med Chem. 2010 Apr 22;53(8):3376-88.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library GPCR Compound Library Drug Repurposing Compound Library Anti-Viral Compound Library Bioactive Compounds Library Max ReFRAME Related Library Clinical Compound Library Bioactive Compound Library

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Keywords

Mavorixafor 558447-26-0 Autophagy GPCR/G Protein Immunology/Inflammation CXCR Human immunodeficiency virus AMD070 HIV AMD-070 inhibit CXC chemokine receptors AMD 070 Inhibitor inhibitor

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