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Mavorixafor trihydrochloride

Catalog No. T10296 CAS 2309699-17-8

Synonyms: AMD-070 trihydrochloride

Mavorixafor trihydrochloride is a selective and orally available CXCR4 antagonist (IC50: 13 nM against CXCR4 125I-SDF binding) and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs (IC50s: 1 and 9 nM).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Mavorixafor trihydrochloride Chemical Structure

Mavorixafor trihydrochloride, CAS 2309699-17-8

Pack Size	Availability	Price/USD
2 mg	5 days	$ 87.00
25 mg	6-8 weeks	$ 652.00
50 mg	6-8 weeks	$ 847.00
100 mg	6-8 weeks	$ 1,390.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Mavorixafor trihydrochloride is a selective and orally available CXCR4 antagonist (IC50: 13 nM against CXCR4 125I-SDF binding) and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs (IC50s: 1 and 9 nM).
Targets&IC50	HIV-1 (NL4.3 strain):9 nM (in PBMCs), HIV-1:26 nM (IC90, in PBMCs), HIV-1 (NL4.3 strain):1 nM (in MT-4 cells), HIV-1 (NL4.3 strain):3 nM (IC90, in MT-4 cells), [125I]-SDF-CXCR4:13 nM
In vitro	Mavorixafor (AMD-070) shows no effect on other chemokine receptors (CCR1, CCR2b, CCR4, CCR5, CXCR1, and CXCR2) [1]. Mavorixafor (6.6 μM) significantly suppresses the anchorage-dependent growth, the migration and matrigel invasion of the B88-SDF-1 cells [2].
In vivo	Mavorixafor, at a dosage of 2 mg/kg administered orally, substantially decreases the count of metastatic lung nodules in mice while concurrently reducing the expression of human Alu DNA, all without causing loss in body weight [2].

Synonyms	AMD-070 trihydrochloride
Molecular Weight	458.86
Formula	C21H30Cl3N5
CAS No.	2309699-17-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 6 mg/mL (13.08 mM), Sonication is recommended.

References and Literature

1. Skerlj RT, et al. Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication. J Med Chem. 2010 Apr 22;53(8):3376-88. 2. Uchida D, et al. Effect of a novel orally bioavailable CXCR4 inhibitor, AMD070, on the metastasis of oral cancer cells. Oncol Rep. 2018 Jul;40(1):303-308.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Mavorixafor trihydrochloride 2309699-17-8 Microbiology/Virology Proteases/Proteasome HIV Protease AMD-070 trihydrochloride AMD-070 AMD 070 Trihydrochloride AMD-070 Trihydrochloride AMD 070 Mavorixafor AMD070 Trihydrochloride Mavorixafor Trihydrochloride AMD070 inhibitor inhibit

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