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Mc-MMAE

Catalog No. T18312 CAS 863971-24-8

Synonyms: Maleimidocaproyl-monomethylauristatin E

Mc-MMAE (Maleimidocaproyl-monomethylauristatin E) is a drug-linker conjugate for ADC. Mc-MMAE is a maleimidocaproyl-conjugated monomethyl auristatin E, which is a potent tubulin inhibitor.

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Mc-MMAE, CAS 863971-24-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 219.00
5 mg	In stock	$ 438.00
10 mg	In stock	$ 686.00
25 mg	In stock	$ 1,070.00
50 mg	In stock	$ 1,450.00
100 mg	In stock	$ 1,950.00
1 mL * 10 mM (in DMSO)	In stock	$ 748.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Mc-MMAE (Maleimidocaproyl-monomethylauristatin E) is a drug-linker conjugate for ADC. Mc-MMAE is a maleimidocaproyl-conjugated monomethyl auristatin E, which is a potent tubulin inhibitor.
In vitro	The production of maleimidocaproyl-MMAE (mc-MMAE) involves introducing maleimidocaproic acid into a dichloromethane solution containing MMAE. This process is then followed by adding diethyl cyanophosphonate and diisopropylethylamine[1].

Synonyms	Maleimidocaproyl-monomethylauristatin E
Molecular Weight	911.18
Formula	C49H78N6O10
CAS No.	863971-24-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 51 mg/mL (55.97 mM)

H2O: < 0.1 mg/mL (insoluble), Sonification and heating to 60℃ are recommended.

References and Literature

1. Sanderson RJ, et al. In vivo drug-linker stability of an anti-CD30 dipeptide-linked auristatin immunoconjugate. Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):843-52.

Citations

1. Wu X, Xu L, Li X, et al.A HER2-targeting antibody-MMAE conjugate RC48 sensitizes immunotherapy in HER2-positive colon cancer by triggering the cGAS-STING pathway.Cell Death & Disease.2023, 14(8): 550.

Related compound libraries

This product is contained In the following compound libraries：

Microtubule-Targeted Compound Library

Related Products

Related compounds with same targets

10-Deacetyltaxol Vindoline TTBK1-IN-2 Zagotenemab Tubulin polymerization-IN-43 DM4 cis-trismethoxy Resveratrol T-1101 tosylate

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Mc-MMAE 863971-24-8 Cytoskeletal Signaling Microtubule Associated Inhibitor Drug-Linker Conjugates for ADC McMMAE Microtubule/Tubulin Mc MMAE inhibit Maleimidocaproyl-monomethylauristatin E inhibitor

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