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Melittin TFA(20449-79-0(free base))

Catalog No. TP1299L CAS TP1299L

Melittin TFA is a small protein containing 26 amino acid residues, is the principal toxic component of bee venom. Melittin is a PLA2 activator, stimulates the activity of the low molecular weight PLA2, while it does not the increase activity of the high molecular weight PLA2.

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Melittin TFA(20449-79-0(free base)) Chemical Structure

Melittin TFA(20449-79-0(free base)), CAS TP1299L

Pack Size	Availability	Price/USD
1 mg	In stock	$ 119.00
5 mg	In stock	$ 289.00
10 mg	In stock	$ 476.00
25 mg	In stock	$ 778.00
50 mg	In stock	$ 1,090.00
100 mg	In stock	$ 1,470.00

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Purity: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

Melittin, an immunologically related PLA2 stimulating peptide from bee venom, increases the activity of the high molecular weight enzyme[1]. Melittin is a cytotoxic peptide from bee venom. Melittin exhibits toxicity against both A2780CR and A2780 cells, with IC50 values of 4.5 and 6.8 μg/mL, respectively. Melittin has natural anti-bacterial, anti-viral, and anti-inflammatory properties. It has also been shown to have diverse anticancer effects in several different cancer cell lines including those of gastric, breast, ovarian, liver, prostate, cervical, and lung origins. The mechanisms by which Melittin, an amphipathic haemolytic peptide, exerts its potential anticancer effects include inhibition of cell proliferation, induction of apoptosis, and direct necrosis. Melittin can also prevent EGF-induced cell invasion through its inhibition of the PI3K/Akt/mTOR signaling pathway, but this is primarily related to breast cancer cells[2].

Molecular Weight	2960.54
Formula	C133H230F3N39O33
CAS No.	TP1299L

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mM

H2O: 20 mM

References and Literature

1. Steiner MR, et al. Responses of purified phospholipases A2 to phospholipase A2 activating protein (PLAP) and Melittin. Biochim Biophys Acta. 1993 Feb 10;1166(1):124-30.

Related compound libraries

This product is contained In the following compound libraries：

NO PAINS Compound Library Peptide Compound Library

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Keywords

Melittin TFA(20449-79-0(free base)) TP1299L Metabolism Phospholipase Melittin TFA(20449 79 0(free base)) Melittin TFA(20449790(free base)) inhibitor inhibit

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