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Mepazine

Catalog No. T16040 CAS 60-89-9

Synonyms: Pecazine

Mepazine (Pecazine) is a potent and selective inhibitor of MALT1. Mepazine inhibits GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM. Mepazine enhances apoptosis and affects the cell viability.

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Mepazine, CAS 60-89-9

Pack Size	Availability	Price/USD
5 mg	In stock	$ 39.00
10 mg	In stock	$ 56.00
25 mg	In stock	$ 93.00
50 mg	In stock	$ 143.00
100 mg	In stock	$ 198.00
200 mg	In stock	$ 312.00
500 mg	In stock	$ 526.00
1 mL * 10 mM (in DMSO)	In stock	$ 48.00

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Purity: 99.99%

Purity: 99.78%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Mepazine (Pecazine) is a potent and selective inhibitor of MALT1. Mepazine inhibits GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM. Mepazine enhances apoptosis and affects the cell viability.
In vitro	Mepazine (5, 10, and 20 μM) decreases cell viability in the ABC-DLBCL cells HBL1, OCI-Ly3, U2932, and TMD8, without significantly affecting GCB-DLBCL cells[1].
In vivo	In female NSG mice with a murine DLBCL xenogeneic tumor model, Mepazine (16 mg/kg; i.p.) interferes with the growth and induces apoptosis of ABC-DLBCL cell line OCI-Ly10. Mepazine strongly impairs the expansion of OCI-Ly10 with daily administration[1].

Synonyms	Pecazine
Molecular Weight	310.46
Formula	C19H22N2S
CAS No.	60-89-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (80.53 mM)

References and Literature

1. Nagel D, et al. Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL. Cancer Cell. 2012 Dec 11;22(6):825-37.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library NF-κB Signaling Compound Library ReFRAME Related Library Drug-induced Liver Injury (DILI) Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Mepazine 60-89-9 Apoptosis Immunology/Inflammation MALT diffuse B cell inhibit large mucosa associated lymphoid tissue lymphoma translocation gene 1 MALT1 lymphoma ABC-DLBCL Pecazine Inhibitor inhibitor

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