Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Metarrestin (ML246) is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, at least in part by interacting with the translation elongation factor eEF1A2.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
2 mg | In stock | $ 48.00 | |
5 mg | In stock | $ 80.00 | |
10 mg | In stock | $ 147.00 | |
25 mg | In stock | $ 313.00 | |
50 mg | In stock | $ 538.00 | |
100 mg | In stock | $ 778.00 | |
500 mg | In stock | $ 1,620.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 84.00 |
Description | Metarrestin (ML246) is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, at least in part by interacting with the translation elongation factor eEF1A2. |
Synonyms | ML246 |
Molecular Weight | 474.6 |
Formula | C31H30N4O |
CAS No. | 1443414-10-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 31.25 mg/mL (65.84 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Metarrestin 1443414-10-5 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis breast ML 246 perinucleolar HeLa ML246 nucleolar Inhibitor PANC1 orally metastatic transcription inhibit eEF1A2 PC3M compartment pancreatic ML-246 inhibitor