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Metergoline

Catalog No. T4008 CAS 17692-51-2

Synonyms: disorder, inhibit, affective, Methergoline, hormone, 5-hydroxytryptamine Receptor, Na+ channels, Na channels, Metergoline, regulation, Inhibitor, dysphoric, prolactin, 5-HT Receptor, Serotonin Receptor, Liserdol, premenstrual, Sodium Channel, psychoactive, Dopamine Receptor

Metergoline is a dopamine agonist and serotonin antagonist. It has been used similarly to BROMOCRIPTINE as a dopamine agonist and also for migraine disorder therapy.

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Metergoline, CAS 17692-51-2

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Metergoline is a dopamine agonist and serotonin antagonist. It has been used similarly to BROMOCRIPTINE as a dopamine agonist and also for migraine disorder therapy.

Synonyms	disorder, inhibit, affective, Methergoline, hormone, 5-hydroxytryptamine Receptor, Na+ channels, Na channels, Metergoline, regulation, Inhibitor, dysphoric, prolactin, 5-HT Receptor, Serotonin Receptor, Liserdol, premenstrual, Sodium Channel, psychoactive, Dopamine Receptor
Molecular Weight	403.52
Formula	C25H29N3O2
CAS No.	17692-51-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 40.4 mg/mL(100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Millan, M.J.,Newman-Tancredi, A.,Lochon, S., et al. Specific labelling of serotonin 5-HT1B receptors in rat frontal cortex with the novel, phenylpiperazine derivative, [3H]GR125,743. A pharmacological characterization. Pharmacol. Biochem. Behav. 71(4), 589-598 (2002). 2. Knight, A.R.,Misra, A.,Quirk, K., et al. Pharmacological characterisation of the agonist radioligand binding site of 5-HT2A, 5-HT2B and 5-HT2C receptors. Naunyn Schmiedebergs Arch. Pharmacol. 370(2), 114-123 (2004) 3. Knight, J.A.,Smith, C.,Toohey, N., et al. Pharmacological analysis of the novel, rapid, and potent inactivation of the human 5-Hydroxytryptamine7 receptor by risperidone, 9-OH-Risperidone, and other inactivating antagonists. Mol. Pharmacol. 75(2), 374-380 (2009). 4. Yeom, H.D. and Lee, J.-H. Regulation of human Kv1.4 channel activity by the antidepressant metergoline. Biol. Pharm. Bull. 39(6), 1069-1072 (2016). 5. Lee, J.-H.,Liu, J.,Shin, M., et al. Metergoline inhibits the neuronal Nav1.2 voltage-dependent Na+ channels expressed in Xenopus oocytes. Acta. Pharmacol. Sin. 35(7), 862-868 (2014).

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Serotonin Receptor-Targeted Compound Library Neurotransmitter Receptor Compound Library Anti-Alzheimer's Disease Compound Library Drug Repurposing Compound Library Neuronal Signaling Compound Library Approved Drug Library FDA-Approved & Pharmacopeia Drug Library Target-Focused Phenotypic Screening Library Anti-Neurodegenerative Disease Compound Library

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