Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Methotrexate metabolite (DAMPA) (DAMPA) is the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist. Methotrexate is used as a chemotherapeutic agent and immunosuppressant.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 39.00 | |
25 mg | In stock | $ 80.00 | |
50 mg | In stock | $ 128.00 | |
100 mg | In stock | $ 193.00 | |
200 mg | In stock | $ 287.00 | |
500 mg | In stock | $ 486.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 39.00 |
Description | Methotrexate metabolite (DAMPA) (DAMPA) is the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist. Methotrexate is used as a chemotherapeutic agent and immunosuppressant. |
In vitro | Methotrexate metabolite was the most active, with 50% inhibitory concentrations in vitro of 446 ng/ml against the antifolate-sensitive strain and 812 ng/ml against the highly resistant strain under physiological folate conditions. Methotrexate metabolite potentiates the activity of the sulfone dapsone, an inhibitor of dihydropteroate synthase, but not that of chlorcycloguanil, a known inhibitor of dihydrofolate reductase (DHFR)[2]. |
Synonyms | DAMPA |
Molecular Weight | 325.33 |
Formula | C15H15N7O2 |
CAS No. | 19741-14-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4 mg/mL (12.30 mM)
You can also refer to dose conversion for different animals. More
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Methotrexate metabolite 19741-14-1 Cell Cycle/Checkpoint Metabolism Antifolate Drug Metabolite Inhibitor DAMPA inhibit inhibitor