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Methyclothiazide

Catalog No. T6581 CAS 135-07-9

Synonyms: Duretic, Enduron, Aquatensen

Methyclothiazide (Aquatensen) is a substituted benzothiadiazide, used to treat high blood pressure and fluid retention caused by various conditions including heart disease.

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Methyclothiazide, CAS 135-07-9

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10 mg	In stock	$ 40.00
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1 mL * 10 mM (in DMSO)	In stock	$ 39.00

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Purity: 95.00%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Methyclothiazide (Aquatensen) is a substituted benzothiadiazide, used to treat high blood pressure and fluid retention caused by various conditions including heart disease.
In vitro	Methyclothiazide (0.1 mM) reduces Ca2+ contractures with maximal inhibition of 90.4% in SHR aortic rings with endothelium. The inhibitory effect of Methyclothiazide (0.1 mM) on Ca2+ contracture is significantly but not totally abolished by the NO synthase inhibitor in SHR aortic rings with functional endothelium. [1] Methyclothiazide (0.1 mM) induces endothelium-dependent inhibition of the vasoconstrictor responses to NE and AVP only in aortas from spontaneously hypertensive rats (SHR) rather than normotensive Wistar Kyoto rats (WKY), and the maximal vasoconstrictive effect of NE and AVP is decreased by 59% and 32.3%, respectively. [2] Methyclothiazide (3.5 mM) inhibits renin release in rat kidney slices. [3]
In vivo	Methyclothiazide (0.1 g/L for the first 5 weeks and 0.2 g/L for the second 2 weeks, drinking water) attenuates development of hypertension in salt-sensitive (DS) rats, but does not affect blood pressure in salt-resistant (DR) ones. [4] The methyclothiazide-treated DOCA-salt rats weigh less than controls or the nonsupplemented DOCA-salt rats at weeks 3 and 4. Methyclothiazide added to the drinking water of DOCA-salt rats attenuates the elevation of blood pressure. [5]

Synonyms	Duretic, Enduron, Aquatensen
Molecular Weight	360.24
Formula	C9H11Cl2N3O4S2
CAS No.	135-07-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 72 mg/mL (199.86 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 4 mg/mL (11.1 mM)

References and Literature

1. Colas B, et al. Eur J Pharmacol, 2000, 408(1), 63-67. 2. Colas B, et al. Fundam Clin Pharmacol, 2000, 14(4), 363-368. 3. Desaulles E, et al. Br J Pharmacol, 1979, 65(2), 193-196. 4. Sasaki S, et al. J Cardiovasc Pharmacol, 1983, 5(3), 378-383. 5. Sasaki S, et al. Jpn Circ J, 1984, 48(11), 1251-1259.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Bioactive Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Anti-Hypertension Compound Library Anti-Cardiovascular Disease Compound Library Human Metabolite Library FDA-Approved & Pharmacopeia Drug Library FDA-Approved Drug Library Approved Drug Library

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Keywords

Methyclothiazide 135-07-9 Metabolism Others Carbonic Anhydrase Duretic Enduron ?stroke,?heart attack,thiazide diuretics Inhibitor inhibit edema blood high pressure Carbonate dehydratase Aquatensen inhibitor

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