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Metipranolol

Catalog No. T8899 CAS 22664-55-7

Metipranolol (Betamann) is a type of β- Adrenergic receptors（ β- A potent antagonist of adrenergic receptor on guinea pig atria β 1- Adrenergic receptors and rat uterus β The 2-adrenergic receptor exhibited the beta blocking potentials (pA2) of 8.3 and 8.4, respectively. It is also a potent substituent in the 3H DHA binding assay, with a ligand concentration of 0.7 nM and a Ki of 39 ± 24 nM.

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Metipranolol, CAS 22664-55-7

Pack Size	Availability	Price/USD
5 mg	In stock	$ 47.00
10 mg	In stock	$ 80.00
25 mg	In stock	$ 178.00
50 mg	In stock	$ 312.00
100 mg	In stock	$ 506.00
1 mL * 10 mM (in DMSO)	In stock	$ 79.00

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Purity: 98.54%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vivo

Metipranolol applied as eye drops promoted cone photoreceptor function in retinas of rd10 mice greater than subcutaneously injected metipranolol.?The reduced nitrosative damage and rescue of functional loss of photoreceptors in rd10 mice suggests that metipranolol, a drug with established ocular safety and tolerability, may have potential for treating patients with retinitis pigmentosa[1].

Molecular Weight	309.4
Formula	C17H27NO4
CAS No.	22664-55-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (80.8 mM)

References and Literature

1. Y Kanan, Khan M , Lorenc V E , et al. Metipranolol Promotes Structure and Function of Retinal Photoreceptors in the rd10 Mouse Model of Human Retinitis Pigmentosa[J]. Journal of Neurochemistry, 2018, 148. 2. Battershill P E , Sorkin E M . Ocular metipranolol. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in glaucoma and ocular hypertension.[J]. Drugs, 1988, 36(5):601.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Adrenergic Receptor-Targeted Compound Library Anti-Alzheimer's Disease Compound Library Anti-Hypertension Compound Library

Related Products

Related compounds with same targets

G-Protein antagonist peptide acetate Phenylephrine Soquinolol ZK-90055 hydrochloride Desipramine hydrochloride Maprotiline hydrochloride Todralazine hydrochloride Medetomidine hydrochloride

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Metipranolol 22664-55-7 GPCR/G Protein Neuroscience Adrenergic Receptor stress Beta Receptor glaucoma lipid antioxidant peroxidation inhibit Nitrosative Inhibitor hypertension inhibitor

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