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Midodrine hydrochloride

Catalog No. T1577   CAS 3092-17-9
Synonyms: Pro-Amatine

Midodrine is converted to its active metabolite, desglymidodrine by deglycination reaction. Desglymidodrine selectively binds to and activates alpha-1-adrenergic receptors of the arteriolar and venous vasculature. This causes smooth muscle contraction and leads to an elevation of blood pressure. Desglymidodrine diffuses poorly across the blood-brain barrier and is therefore not associated with effects on the central nervous system. Midodrine hydrochloride (Pro-Amatine) is the hydrochloride salt form of midodrine, a direct-acting prodrug and sympathomimetic agent with antihypotensive properties.

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Midodrine hydrochloride Chemical Structure
Midodrine hydrochloride, CAS 3092-17-9
Pack Size Availability Price/USD Quantity
5 mg In stock $ 39.00
10 mg In stock $ 64.00
25 mg In stock $ 128.00
50 mg In stock $ 193.00
100 mg In stock $ 287.00
1 mL * 10 mM (in DMSO) In stock $ 43.00
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Purity: 99.36%
Purity: 99.06%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Midodrine is converted to its active metabolite, desglymidodrine by deglycination reaction. Desglymidodrine selectively binds to and activates alpha-1-adrenergic receptors of the arteriolar and venous vasculature. This causes smooth muscle contraction and leads to an elevation of blood pressure. Desglymidodrine diffuses poorly across the blood-brain barrier and is therefore not associated with effects on the central nervous system. Midodrine hydrochloride (Pro-Amatine) is the hydrochloride salt form of midodrine, a direct-acting prodrug and sympathomimetic agent with antihypotensive properties.
In vivo The preferential cyclooxygenase-2 inhibitor etoricoxib significantly reduces the anticonvulsant action of phenytoin and significantly increases the beneficial action of diazepam against maximal electroshock and pentylenetetrazole-induced convulsions in a mouse model[1]. Etoricoxib has the potential to act as an anti-apoptotic and anti- proliferative agent in the colon[2].
Synonyms Pro-Amatine
Molecular Weight 290.74
Formula C12H19ClN2O4
CAS No. 3092-17-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (189.17 mM)

TargetMolReferences and Literature

1. Buckner SA, et al. Eur J Pharmacol. 2002 Aug 2;449(1-2):159-65.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Neurodegenerative Disease Compound Library Bioactive Compound Library Anti-Obesity Compound Library Cardiotoxicity Compound Library Drug Repurposing Compound Library Endocrinology-Hormone Compound Library FDA-Approved & Pharmacopeia Drug Library Anti-COVID-19 Compound Library

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Keywords

Midodrine hydrochloride 3092-17-9 GPCR/G Protein Neuroscience Adrenergic Receptor Midodrine Hydrochloride Pro-Amatine inhibitor inhibit

 

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