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Miransertib

Catalog No. T3467 CAS 1313881-70-7

Synonyms: ARQ-092, AKT inhibitor 2

Miransertib (ARQ-092) is an orally bioavailable, selective, and potent allosteric Akt inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Miransertib, CAS 1313881-70-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 44.00
5 mg	In stock	$ 98.00
10 mg	In stock	$ 172.00
25 mg	In stock	$ 363.00
50 mg	In stock	$ 597.00
100 mg	In stock	$ 955.00
500 mg	In stock	$ 1,890.00
1 mL * 10 mM (in DMSO)	In stock	$ 116.00

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Purity: 99.93%

Purity: 98.83%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Miransertib (ARQ-092) is an orally bioavailable, selective, and potent allosteric Akt inhibitor.
Targets&IC50	Akt3:8.1 nM, Akt2:14 nM, Akt1:2.7 nM
In vitro	ARQ 092 blocks membrane translocation of inactive AKT and even dephosphorylates the membrane-associated active form, thereby perturbing AKT activity. Treatment with 50-500 nM ARQ 092 significantly blocks αMβ2 integrin function in neutrophils and reduces P-selectin exposure and glycoprotein Ib/IX/V-mediated agglutination in platelets[2]. In a large panel of diverse cancer cell lines, ARQ 092 inhibits proliferation across multiple tumor types but are most potent in leukemia, breast, endometrial, and colorectal cancer cell lines. Moreover, inhibition by ARQ 092 is more prevalent in cancer cell lines containing PIK3CA/PIK3R1 mutations compared to those with wt-PIK3CA/PIK3R1 or PTEN mutations[1]. ARQ 092 targets the PI3K/AKT pathway and AKT specifically and reduces phosphorylation of GSK3α and GSK3β in mutation-positive cells[3].
Cell Research	Cells (MDA-MB-453: 1.5×106; NCI-H1650: 1×106; KU-19-19: 0.7×106) are plated into 6 well plates, left overnight, and then treated with full media containing different concentrations (0, 0.012, 0.037, 0.11, 0.33, and 1 μM) of AKT inhibitors (ARQ 092, ARQ 751, MK-2206, GDC-0068) for 2 hours. Cells are treated under designated conditions and lysates are extracted. Proteins are resolved from extracts using SDS-PAGE followed by immunoblotting. (Only for Reference)

Synonyms	ARQ-092, AKT inhibitor 2
Molecular Weight	432.52
Formula	C27H24N6
CAS No.	1313881-70-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (115.6 mM)

References and Literature

1. Yu Y, et al. PLoS One. 2015, 10(10):e20140479. 2. Kim K, et al. Haematologica. 2017, 102(2):246-259. 3. Lindhurst MJ, et al. Sci Rep. 2015, 5:17162. 4. Han P, Hou Y, Zhao Y, et al. Low-dose decitabine modulates T cell homeostasisand restores immune tolerance in immune thrombocytopenia[J]. Blood. 2021

Citations

1. Han P, Hou Y, Zhao Y, et al. Low-dose decitabine modulates T cell homeostasisand restores immune tolerance in immune thrombocytopenia. Blood. 2021

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Inhibitor Library Drug Repurposing Compound Library Anti-Parasitic Compound Library Kinase Inhibitor Library Bioactive Compounds Library Max Reprogramming Compound Library Anti-Obesity Compound Library Anti-Infection Compound Library

Related Products

Related compounds with same targets

PF-AKT400 Triciribine phosphate AT13148 Haginin A Dehydroglyasperin D Lupalbigenin PI3K/Akt/mTOR-IN-2 MKC-1

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Miransertib 1313881-70-7 Cytoskeletal Signaling Microbiology/Virology PI3K/Akt/mTOR signaling Parasite Akt anti-proliferative PKB Akt1 Protein kinase B Inhibitor ARQ092 Akt3 AKT1-E17K Akt2 inhibit ARQ-092 p-PRAS40 ARQ 092 anti-tumor p-Akt AKT inhibitor 2 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.