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Moexipril hydrochloride

Catalog No. T6595 CAS 82586-52-5

Synonyms: Moexipril HCl, RS-10085, SPM 925, CI-925

Moexipril hydrochloride (Moexipril HCl) is a potent orally active nonsulfhydrylangiotensin converting enzyme (ACE)inhibitor, used for the treatment of hypertension and congestive heart failure.

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Moexipril hydrochloride Chemical Structure

Moexipril hydrochloride, CAS 82586-52-5

Pack Size	Availability	Price/USD
10 mg	In stock	$ 50.00
50 mg	In stock	$ 63.00
100 mg	In stock	$ 81.00
200 mg	In stock	$ 113.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 89.27%

Biological Description

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Description	Moexipril hydrochloride (Moexipril HCl) is a potent orally active nonsulfhydrylangiotensin converting enzyme (ACE)inhibitor, used for the treatment of hypertension and congestive heart failure.
Targets&IC50	ACE:0.041 µM
In vitro	Moexipril dose-dependently reduces the percentage of damaged neurons, as well as mitochondrial reactive oxygen species generation induced by glutamate, staurosporine or Fe2+/3+. Moexipril and enalapril attenuates staurosporine-induced neuronal apoptosis as determined by nuclear staining with Hoechst 33258. [1]
In vivo	Moexipril (0.3 mg/kg) significantly reduces brain damage after focal ischemia as compared to control mice. Moexipril (0.01 mg/kg) is able to reduce the infarct volume in the rat model after focal cerebral ischemia. [1] Moexipril reduces blood pressure after the first week of treatment but it has no apparent effect on either the proximal tibial metaphysis or the tibial shaft in ovariectomized (OVX) spontaneously hypertensive rats (SHR). Moexipril combined with hydrochlorothiazide (HCTZ) exhibits a much more potent hypotensive effect and has the same effect on bone mass and dynamic end-points as HCTZ alone. [2] Moexiprilat exhibits a higher inhibitory potency than enalaprilat against both plasma ACE and purified ACE from rabbit lung. Moexipril (0.1-30 mg/kg/day) lowers blood pressure and differentially inhibits ACE activity in plasma, lung, aorta, heart and kidney in a dose-dependent fashion. Moexipril (10 mg/kg/day) leads to comparable decreases in blood pressure, inhibition of plasma ACE and reduction of plasma angiotensinogen and to a similar attenuation of the pressor responses to angiotensin I and potentiation of the depressor responses to bradykinin. [3]

Synonyms	Moexipril HCl, RS-10085, SPM 925, CI-925
Molecular Weight	535.03
Formula	C27H34N2O7·HCl
CAS No.	82586-52-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 53.5 mg/mL (100 mM)

References and Literature

1. Ravati A, et al. Eur J Pharmacol,1999, 373(1), 21-33. 2. Ma YF, et al. J Endocrinol,1997, 154(3), 467-474. 3. Edling O, et al. J Pharmacol Exp Ther,1995, 275(2), 854-863.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Anti-Cancer Drug Library Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Anti-Hypertension Compound Library Bioactive Compound Library Drug-induced Liver Injury (DILI) Compound Library Anti-Cardiovascular Disease Compound Library

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Keywords

Moexipril hydrochloride 82586-52-5 Apoptosis Endocrinology/Hormones RAAS orally active Ischemic brain injury inhibit hepatic disease Angiotensin-converting Enzyme (ACE) hydrochlorothiazide essential hypertension antihypertensive moexiprilat angiotensin II Moexipril Hydrochloride SPM925 cardiovascular disease Inhibitor RS 10085 CI 925 Moexipril HCl CI925 RS-10085 SPM 925 CI-925 SPM-925 hypertension RS10085 Moexipril inhibitor

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