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Mollugin

Catalog No. T3673 CAS 55481-88-4

Synonyms: Rubimaillin

Mollugin (Rubimaillin) may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway. Mollugin as a candidate for a chemotherapeutic agent in OSCCs via the upregulation of the HO-1 and Nrf2 pathways and the downregulation of NF- κ B. Mollugin may be a novel therapeutic candidate for bone loss-associated disorders including osteoporosis, rheumatoid arthritis, and periodontitis. Also, it has anticancer efficacy, can modulate the HER2 pathway in HER2-overexpressing Y cells with a potential role in the treatment and prevention of human breast and ovarian Y with HER2 overexpression.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Mollugin, CAS 55481-88-4

Pack Size	Availability	Price/USD
5 mg	In stock	$ 39.00
10 mg	In stock	$ 72.00
25 mg	In stock	$ 128.00
50 mg	In stock	$ 198.00
100 mg	In stock	$ 297.00
500 mg	In stock	$ 733.00

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Purity: 98.31%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Source

Natural Products > Rubiaceae > Rubia

Synonyms	Rubimaillin
Molecular Weight	284.31
Formula	C17H16O4
CAS No.	55481-88-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/mL(70.3 mM)

Chloroform, Dichloromethane, Ethyl Acetate, Acetone: Soluble

References and Literature

1. Zhang L, et al. Biochem Biophys Res Commun. 2014 Jul 18;450(1):247-54. 2. Baek JM, et al. Phytomedicine. 2015 Jan 15;22(1):27-35. 3. Do MT, et al. J Cell Physiol. 2013 May;228(5):1087-97.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Anti-Cancer Active Compound Library Inhibitor Library Kinase Inhibitor Library Anti-Aging Compound Library Apoptosis Compound Library RO5 Drug-like Natural Product Library Traditional Chinese Medicine Monomer Library JAK-STAT Compound Library Epigenetics Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Mollugin 55481-88-4 Angiogenesis Chromatin/Epigenetic JAK/STAT signaling Stem Cells Tyrosine Kinase/Adaptors JAK HER NF-κB c-Myc Nuclear factor-kappaB Inhibitor inhibit Apoptosis HEK293 H22-tumor HepG2 cells Vascular endothelial growth factor receptor VEGFR Reactive Oxygen Species ROS HeLa antitumor Liver cancer Hep3B Myc DNA damage Rubimaillin anti-hepatocellular Nuclear factor-κB inhibitor

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