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Monensin sodium salt

Catalog No. T1033 CAS 22373-78-0

Synonyms: Sodium Monensin, Monensin A sodium salt

Monensin sodium is an antiprotozoal agent produced by Streptomyces cinnamonensis.Monensin sodium salt (Monensin A sodium salt) causes a marked enlargement of the MVBs and regulates exosome secretion

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Monensin sodium salt, CAS 22373-78-0

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50 mg	In stock	$ 30.00
100 mg	In stock	$ 42.00
200 mg	In stock	$ 58.00

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Purity: 98.9%

Purity: 98.74%

Purity: 90%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Monensin sodium is an antiprotozoal agent produced by Streptomyces cinnamonensis.Monensin sodium salt (Monensin A sodium salt) causes a marked enlargement of the MVBs and regulates exosome secretion
In vitro	Monensin sodium salt (Coban), isolated from Streptomyces cinnamonensis, is a well-known representative of naturally polyether ionophore antibiotics. Monensin is an ionophore related to the crown ethers with a preference to form complexes with monovalent cations such as: Li+, Na+, K+, Rb+, Ag+, and TI+. [1] Monensin A is able to transport these cations across lipid membranes of cells, playing an important role as an Na+/H+ antiporter. It blocks intracellular protein transport, and exhibits antibiotic, antimalarial, and other biological activities. [2] The antibacterial properties of monensin and its derivatives are a result of their ability to transport metal cations through cellular and subcellular membranes. [3]
In vivo	LD50: Mice 335 mg/kg (i.g.) [4]; Rats 36.5 mg/kg (i.g.); Chickens 185 mg/kg (i.g.). [5]

Synonyms	Sodium Monensin, Monensin A sodium salt
Molecular Weight	692.85
Formula	C36H61NaO11
CAS No.	22373-78-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 69.3 mg/mL (100 mM)

References and Literature

1. Pinkerton M, et al. J Mol Biol, 1970, 49(3), 533-546. 2. Mollenhauer HH, et al. Biochim Biophys Acta, 1990, 1031(2), 225-246. 3. Huczynski A, et al. Bioorg Med Chem Lett, 2008, 18(8), 2585-2589.

Citations

1. Duan X, Chen H, Zhou X, et al. EBV infection in epithelial malignancies induces resistance to antitumor natural killer cells via F3-mediated platelet aggregation. Cancer Research. 2022 2. Zhang X, Wu S, Liu J, et al.A Mosaic Nanoparticle Vaccine Elicits Potent Mucosal Immune Response with Significant Cross‐Protection Activity against Multiple SARS‐CoV‐2 Sublineages.Advanced Science.2023: 2301034. 3. He X, Zhang X, Wu B, et al.The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis.Nature Immunology.2024: 1-11.

Related compound libraries

This product is contained In the following compound libraries：

Microbial Natural Product Library Antiparasitic Natural Product Library Membrane Protein-targeted Compound Library Exosome Compound Library Anti-COVID-19 Compound Library Ion Channel Inhibitor Library Anti-Bacterial Compound Library FDA-Approved & Pharmacopeia Drug Library Anti-Cancer Compound Library Antibiotics Library

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Related compounds with same targets

Clopamide Stauntosaponin A Pterinotoxin-1 Evenamide Jingzhaotoxin-34 Propoxycaine hydrochloride Oxybuprocaine hydrochloride QX-314 chloride

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Keywords

Monensin sodium salt 22373-78-0 Membrane transporter/Ion channel Microbiology/Virology Antibiotic Sodium Channel Antibacterial Sodium/hydrogen Exchanger Monensin Monensin sodium Monensin A sodium inhibit Monensin A Bacterial Sodium Monensin Inhibitor Monensin A sodium salt Na+/H+ Exchanger (NHE) Sodium-hydrogen Exchanger inhibitor

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