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Montelukast sodium

Catalog No. T1677L CAS 151767-02-1

Synonyms: MK0476

Montelukast sodium (MK0476) is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked to rare cases of clinically apparent liver injury.

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Montelukast sodium, CAS 151767-02-1

Pack Size	Availability	Price/USD
50 mg	In stock	$ 41.00
100 mg	In stock	$ 66.00
500 mg	In stock	$ 132.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 99.89%

Purity: 99.65%

Purity: 99.41%

Purity: 99.35%

Biological Description

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Storage & Solubility Information

Description	Montelukast sodium (MK0476) is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked to rare cases of clinically apparent liver injury.
In vitro	Administering 6 mg/kg of Montelukast once daily for 20 days significantly inhibits the increase of eosinophils in both the BAL fluid and lung tissue in mice stimulated by OVA, while also elevating the IL-5 levels in the BAL fluid. OVA stimulation leads to an upsurge in CysLT1 receptor mRNA expression but a decrease in CysLT2 receptor mRNA expression. Following OVA stimulation, Montelukast suppresses the elevated expression of CysLT1 without diminishing the expression of CysLT2.
In vivo	Montelukast acts by binding to the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchi, thereby blocking the effects of leukotriene D4. This action prevents airway edema, smooth muscle contraction, and secretion of viscous liquids, reduces bronchoconstriction caused by leukotrienes, and diminishes inflammation occurrence.
Cell Research	Nasal mucosa and polyp epithelial cells are stimulated with fetal bovine serum (FBS) with or without MK for 24 hours, and cytokine concentrations in epithelial secretions are measured by ELISA. After incubating peripheral blood eosinophils with epithelial cell-conditioned media (ECM) with or without montelukast up to 3 days, eosinophil survival is assessed by Trypan blue dye exclusion[1].

Synonyms	MK0476
Molecular Weight	608.17
Formula	C35H35ClNNaO3S
CAS No.	151767-02-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 30.4 mg/mL (50 mM)

DMSO: 60.8 mg/mL (100 mM), The compound is unstable in solution, please use soon.

References and Literature

1. Montelukast 2. Zhang YJ, et al. Acta Pharmacol Sin, 2004, 25(10), 1341-1346

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Autophagy Compound Library Bioactive Compounds Library Max FDA-Approved Drug Library Approved Drug Library Bioactive Compound Library Clinical Compound Library

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Keywords

Montelukast sodium 151767-02-1 GPCR/G Protein Immunology/Inflammation Leukotriene Receptor LTR Cysltr1 liver ischemia–reperfusion injury damage antioxidant intestinal Inhibitor Montelukast asthma cysteinyl icardiac inhibit leukotriene MK-0476 MK0476 MK 0476 inhibitor

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