Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Motixafortide TFA(664334-36-5,Free) (BKT140 TFA) is an antagonist of CXCR4 with IC50 of ~1 nM. It induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 117.00 | |
5 mg | In stock | $ 330.00 | |
10 mg | In stock | $ 495.00 | |
25 mg | In stock | $ 791.00 | |
50 mg | In stock | $ 1,120.00 | |
100 mg | In stock | $ 1,490.00 |
Description | Motixafortide TFA(664334-36-5,Free) (BKT140 TFA) is an antagonist of CXCR4 with IC50 of ~1 nM. It induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression. |
Targets&IC50 | CXCR4:~1 nM |
In vitro | Treatment with BL-8040 induces the robust mobilization of AML blasts from the BM. In addition, AML cells exposed to BL-8040 undergoes differentiation. BL-8040 induces the apoptosis of AML cells in vitro, which is mediated by the up-regulation of miR-15a/miR-16-1, resulting in down-regulation of the target genes BCL-2, MCL-1 and cyclin-D1. Overexpression of miR-15a/miR-16-1 directly induces leukemic cell death. BL-8040-induced apoptosis is also mediated by the inhibition of survival signals via the AKT/ERK pathways. |
In vivo | BL-8040 also synergizes with FLT3 inhibitors to induce AML cell death. Importantly, this combined treatment prolongs the survival of tumor-bearing mice and reduces minimal residual disease in vivo. |
Synonyms | TF 14016 TFA, BKT140 TFA, BL-8040 TFA, T140 TFA |
Molecular Weight | 2273.54 |
Formula | C99H145F4N33O21S2 |
CAS No. | T14665L |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 100 mg/mL (46.31 mM), sonification is recommended.
DMSO: 100 mg/mL (46.31 mM)
You can also refer to dose conversion for different animals. More
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Motixafortide TFA(664334-36-5,Free) T14665L Autophagy GPCR/G Protein Immunology/Inflammation CXCR TF 14016 TFA BKT140 TFA Motixafortide TFA(664334 36 5,Free) BL-8040 TFA T140 TFA Motixafortide TFA(664334365,Free) inhibitor inhibit