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N-(p-amylcinnamoyl) Anthranilic Acid

Catalog No. T5454   CAS 110683-10-8
Synonyms: ACA

N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker.

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N-(p-amylcinnamoyl) Anthranilic Acid Chemical Structure
N-(p-amylcinnamoyl) Anthranilic Acid, CAS 110683-10-8
Pack Size Availability Price/USD Quantity
25 mg In stock $ 39.00
50 mg In stock $ 63.00
1 mL * 10 mM (in DMSO) In stock $ 39.00
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Purity: 99.35%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker.
In vitro ACA modulates different TRP channels most probably by a direct interaction. Owing to its high potency and efficacy on TRPM2, ACA can serve, in combination with other blockers, as a pharmacological tool for studying H2O2-induced Ca2+ signalling and biological functions of TRPM2 channels in native cells[1].ACA is also an inhibitor of phospholipase A2, blocking the release of arachidonic acid when given at 50 μM[2].
Cell Research Measurements of [Ca2+]i were carried out on TRPM8-transfected HEK293 cells grown in 96-well microplates. Cells were loaded with 1?μm fluo-4 for 30?min at 37°C in a standard solution. Subsequently, the standard solution was exchanged for a solution containing 1?mm EGTA instead of 2?mm CaCl2, and plates were inserted into a fluorometric-imaging plate reader. The fluorescence was excited at 485?nm, emitted at 535?nm and corrected for the background fluorescence. Fluorescence values were measured after addition of ACA, menthol and 3?mm CaCl2 to the EGTA-containing solution. ACA, menthol and 3?mm CaCl2 were applied consecutively in the given order with a time delay of 2?min between each application[1].
Synonyms ACA
Molecular Weight 337.41
Formula C21H23NO3
CAS No. 110683-10-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (370.47 mM)

H2O: Insoluble

TargetMolReferences and Literature

1. Kraft R, et al. Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid. Br J Pharmacol. 2006 Jun;148(3):264-73. 2. Konrad R J , Jolly Y C , Major C , et al. Inhibition of phospholipase A2 and insulin secretion in pancreatic islets[J]. Biochimica et Biophysica Acta, 1992, 1135(2):215-220.

TargetMolCitations

1. Yıldızhan K, Huyut Z, Altındağ F Involvement of TRPM2 Channel on Doxorubicin‑Induced Experimental Cardiotoxicity Model: Protective Role of Selenium. Biological Trace Element Research. 2022: 1-12 2. Yıldızhan K, Huyut Z, Altındağ F. Involvement of TRPM2 Channel on Doxorubicin-Induced Experimental Cardiotoxicity Model: Protective Role of Selenium. Biological Trace Element Research. 2022: 1-12. 3. YILDIZHAN K, HUYUT Z, ALTINDAĞ F, et al.EFFECT OF SELENIUM AND N-(P-AMYLCINNAMOYL) ANTHRANILIC ACID ON DOXORUBICIN-INDUCED KIDNEY INJURY IN RATS.İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi.11(1): 1181-1191. 4. Zhu Y, Gu H, Yang J, et al.An Injectable silk-based hydrogel as a novel biomineralization seedbed for critical-sized bone defect regeneration.Bioactive Materials.2024, 35: 274-290.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Compound Library NO PAINS Compound Library Inhibitor Library Bioactive Compound Library Metabolism Compound Library Bioactive Compounds Library Max Anti-Obesity Compound Library Anti-Metabolism Disease Compound Library Lipid Metabolism Compound Library Ion Channel Inhibitor Library

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Keywords

N-(p-amylcinnamoyl) Anthranilic Acid 110683-10-8 Membrane transporter/Ion channel Metabolism TRP/TRPV Channel Phospholipase N(pamylcinnamoyl) Anthranilic Acid N (p amylcinnamoyl) Anthranilic Acid inhibit TRP Channel ACA Transient receptor potential channels Inhibitor inhibitor

 

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